TY - JOUR
T1 - Antibody to peptides of human myelin basic protein in post-rabies vaccine endophalomyelitis sera
AU - Ubol, Sukathida
AU - Hemachudha, Thivarat
AU - Whitaker, John N.
AU - Griffin, Diane E.
N1 - Funding Information:
This research was supported in part by a grant from the National Multiple Sclerosis Society (D.E.G.), NIH grant NS23240 from the National Institutes of Health (J.N.W.), the Research Program of the Veterans Administration (J.N.W.) and Chulalongkorn University (T.H.).
PY - 1990/2
Y1 - 1990/2
N2 - Development of neurologic complications after Semple rabies vaccine is closely linked to deveopment of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassays in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89,and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic comlication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 42-170.
AB - Development of neurologic complications after Semple rabies vaccine is closely linked to deveopment of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassays in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89,and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic comlication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 42-170.
KW - Demyelinating disease
KW - Myelin basic protein
KW - Rabies vaccine
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U2 - 10.1016/0165-5728(90)90081-W
DO - 10.1016/0165-5728(90)90081-W
M3 - Article
C2 - 1688875
AN - SCOPUS:0025019309
SN - 0165-5728
VL - 26
SP - 107
EP - 111
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 2
ER -