Antibody to peptides of human myelin basic protein in post-rabies vaccine endophalomyelitis sera

Sukathida Ubol, Thivarat Hemachudha, John N. Whitaker, Diane E. Griffin

Research output: Contribution to journalArticlepeer-review

Abstract

Development of neurologic complications after Semple rabies vaccine is closely linked to deveopment of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassays in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89,and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic comlication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 42-170.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalJournal of Neuroimmunology
Volume26
Issue number2
DOIs
StatePublished - Feb 1990

Keywords

  • Demyelinating disease
  • Myelin basic protein
  • Rabies vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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