Abstract
The 1° and 2° antibody response of adjuvant arthritic rats to a soluble mycobacterial lipoprotein preceded the development of arthritis. In contrast, delayed hypersensitivity reactions to PPD paralleled disease activity. Treatment with immunosuppressive agents indicated that complete suppression of disease in the noninjected paw could occur without effect on the humoral response, but the delayed skin reaction was suppressed at all doses. It is suggested that the humoral antibody response to mycobacterial antigens may have relevance to the regulation of the disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-292 |
| Number of pages | 10 |
| Journal | Arthritis & Rheumatism |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1972 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology
- Pharmacology (medical)