Antibody to mycobacterial antigens in adjuvant arthritis (AA). I. Relationship to disease and delayed hypersensitivity

Robert J. Perper, Arnold L. Oronsky, Vincent Blancuzzi

Research output: Contribution to journalArticle

Abstract

The 1° and 2° antibody response of adjuvant arthritic rats to a soluble mycobacterial lipoprotein preceded the development of arthritis. In contrast, delayed hypersensitivity reactions to PPD paralleled disease activity. Treatment with immunosuppressive agents indicated that complete suppression of disease in the noninjected paw could occur without effect on the humoral response, but the delayed skin reaction was suppressed at all doses. It is suggested that the humoral antibody response to mycobacterial antigens may have relevance to the regulation of the disease.

Original languageEnglish (US)
Pages (from-to)283-292
Number of pages10
JournalArthritis & Rheumatism
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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