Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen

Luis R. Martinez, Dariush Moussai, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.

Original languageEnglish (US)
Pages (from-to)3674-3679
Number of pages6
JournalInfection and immunity
Volume72
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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