Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen

Luis R. Martinez; Dariush Moussai; Arturo Casadevall

doi:10.1128/IAI.72.6.3674-3679.2004

Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen

Luis R. Martinez, Dariush Moussai, Arturo Casadevall

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.

Original language	English (US)
Pages (from-to)	3674-3679
Number of pages	6
Journal	Infection and immunity
Volume	72
Issue number	6
DOIs	https://doi.org/10.1128/IAI.72.6.3674-3679.2004
State	Published - Jun 2004
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.72.6.3674-3679.2004

Cite this

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abstract = "Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.",

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AB - Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.

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Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen

Abstract

ASJC Scopus subject areas

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