Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude

Godfree Mlambo, Susan L. Mutambu, Takafira Mduluza, White Soko, Joel Mbedzi, James Chivenga, David E. Lanar, Sanjay Singh, Daniel Carucci, Armin Gemperli, Nirbhay Kumar

Research output: Contribution to journalArticle

Abstract

Antibody levels against malaria antigens were measured among patients presenting with uncomplicated malaria at health centers from three locations in Zimbabwe (Bindura, Chiredzi and Kariba) that are distinct with regard to altitude and climatic conditions. Antibody levels were determined by ELISA using the antigens, apical membrane antigen 1 (AMA-1), erythrocyte binding antigen 175 (EBA-175), circumsporozoite surface protein (CSP), merozoite surface protein 1 (MSP-1) and Pfg27. For all the antigens tested, IgG and IgM levels were higher for Bindura (altitude 1100 m) compared to Kariba (

Original languageEnglish (US)
Pages (from-to)70-78
Number of pages9
JournalActa Tropica
Volume100
Issue number1-2
DOIs
Publication statusPublished - Nov 2006

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Keywords

  • Antibody responses
  • Malaria vaccine
  • P. falciparum
  • Transmission
  • Zimbabwe

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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