Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

Maria E. Lorenzo, Andrea Hodgson, Dionne P. Robinson, Jenifer B. Kaplan, Andrew Pekosz, Sabra L. Klein

Research output: Contribution to journalArticlepeer-review

Abstract

A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.

Original languageEnglish (US)
Pages (from-to)9246-9255
Number of pages10
JournalVaccine
Volume29
Issue number49
DOIs
StatePublished - Nov 15 2011

Keywords

  • Humoral immunity
  • Influenza vaccine
  • Sex difference

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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