@article{e5570f860ad5480ca6c77abc74a94f38,
title = "Antibody responses after immunization with killed oral cholera vaccines during the 1985 vaccine field trial in Bangladesh",
abstract = "Sera collected during the 1985 oral cholera vaccine trial in Matlab, Bangladesh, which demonstrated efficacy of a whole cell combined with cholera B subunit vaccine (WC/BS) and a whole cell only vaccine (WC), were analyzed for antitoxin and vibriocidal antibodies. Before vaccines were given, antitoxin titers were highest in children, especially those with O blood group, whereas vibriocidal titers rose throughout life. Two weeks after three doses of vaccine, geometric mean antitoxin titers were 2.5-4.5 times higher in vaccinees who received the WC/BS vaccine; the vibriocidal titers were 1.3-2.1 times higher in vaccinees who received either vaccine. The titer elevations were relatively brief and were barely detectable 7 months after the third dose even though significant levels of protection persisted ≥3 years. Thus, the oral vaccines induced a serum response in this large field trial that was similar to that seen in earlier pilot studies, but the duration of the serum responses was much shorter than the duration of the protection.",
author = "Sack, {D. A.} and Clemens, {J. D.} and S. Huda and Harris, {J. R.} and Khan, {M. R.} and J. Chakraborty and M. Yunus and J. Gomes and O. Siddique and F. Ahmed and Kay, {B. A.} and {Van Loon}, {F. P.L.} and Rao, {M. R.} and Svennerholm, {A. M.} and J. Holmgren",
note = "Funding Information: Received 12 December 1989; revised 26 March 1991. Study participants gave signed informed consent. The study was approved by the Ethical Review Committee of the International Centre for Diarrheal Disease Research, Bangladesh. Financial and product support: United States Agency for International Development, World Health Organization, government of Japan, and the Swedish Agency for Research Cooperation. The vaccine was produced and donated by Institut Merieux, Lyon, France. Reprints or correspondence: Dr. D. A. Sack, Johns Hopkins School of Hygiene and Public Health, Department of International Health, Room 5521, 615 N. Wolfe St., Baltimore, MD 21205. * Present addresses: Division of Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland (J.D.C., M.R.R.), Office of Health, US Agency for International Development, Washington, DC (J.R.H.); University of Maryland School of Medicine, Baltimore (B.A.K.).",
year = "1991",
month = aug,
doi = "10.1093/infdis/164.2.407",
language = "English (US)",
volume = "164",
pages = "407--411",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",
}