Abstract
Sera collected during the 1985 oral cholera vaccine trial in Matlab, Bangladesh, which demonstrated efficacy of a whole cell combined with cholera B subunit vaccine (WC/BS) and a whole cell only vaccine (WC), were analyzed for antitoxin and vibriocidal antibodies. Before vaccines were given, antitoxin titers were highest in children, especially those with O blood group, whereas vibriocidal titers rose throughout life. Two weeks after three doses of vaccine, geometric mean antitoxin titers were 2.5-4.5 times higher in vaccinees who received the WC/BS vaccine; the vibriocidal titers were 1.3-2.1 times higher in vaccinees who received either vaccine. The titer elevations were relatively brief and were barely detectable 7 months after the third dose even though significant levels of protection persisted ≥3 years. Thus, the oral vaccines induced a serum response in this large field trial that was similar to that seen in earlier pilot studies, but the duration of the serum responses was much shorter than the duration of the protection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 407-411 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 164 |
| Issue number | 2 |
| State | Published - Aug 1991 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
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Antibody responses after immunization with killed oral cholera vaccines during the 1985 vaccine field trial in Bangladesh. / Sack, David Allen; Clemens, J. D.; Huda, S.; Harris, J. R.; Khan, M. R.; Chakraborty, J.; Yunus, M.; Gomes, J.; Siddique, O.; Ahmed, F.; Kay, B. A.; Van Loon, F. P L; Rao, M. R.; Svennerholm, A. M.; Holmgren, J.
In: Journal of Infectious Diseases, Vol. 164, No. 2, 08.1991, p. 407-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibody responses after immunization with killed oral cholera vaccines during the 1985 vaccine field trial in Bangladesh
AU - Sack, David Allen
AU - Clemens, J. D.
AU - Huda, S.
AU - Harris, J. R.
AU - Khan, M. R.
AU - Chakraborty, J.
AU - Yunus, M.
AU - Gomes, J.
AU - Siddique, O.
AU - Ahmed, F.
AU - Kay, B. A.
AU - Van Loon, F. P L
AU - Rao, M. R.
AU - Svennerholm, A. M.
AU - Holmgren, J.
PY - 1991/8
Y1 - 1991/8
N2 - Sera collected during the 1985 oral cholera vaccine trial in Matlab, Bangladesh, which demonstrated efficacy of a whole cell combined with cholera B subunit vaccine (WC/BS) and a whole cell only vaccine (WC), were analyzed for antitoxin and vibriocidal antibodies. Before vaccines were given, antitoxin titers were highest in children, especially those with O blood group, whereas vibriocidal titers rose throughout life. Two weeks after three doses of vaccine, geometric mean antitoxin titers were 2.5-4.5 times higher in vaccinees who received the WC/BS vaccine; the vibriocidal titers were 1.3-2.1 times higher in vaccinees who received either vaccine. The titer elevations were relatively brief and were barely detectable 7 months after the third dose even though significant levels of protection persisted ≥3 years. Thus, the oral vaccines induced a serum response in this large field trial that was similar to that seen in earlier pilot studies, but the duration of the serum responses was much shorter than the duration of the protection.
AB - Sera collected during the 1985 oral cholera vaccine trial in Matlab, Bangladesh, which demonstrated efficacy of a whole cell combined with cholera B subunit vaccine (WC/BS) and a whole cell only vaccine (WC), were analyzed for antitoxin and vibriocidal antibodies. Before vaccines were given, antitoxin titers were highest in children, especially those with O blood group, whereas vibriocidal titers rose throughout life. Two weeks after three doses of vaccine, geometric mean antitoxin titers were 2.5-4.5 times higher in vaccinees who received the WC/BS vaccine; the vibriocidal titers were 1.3-2.1 times higher in vaccinees who received either vaccine. The titer elevations were relatively brief and were barely detectable 7 months after the third dose even though significant levels of protection persisted ≥3 years. Thus, the oral vaccines induced a serum response in this large field trial that was similar to that seen in earlier pilot studies, but the duration of the serum responses was much shorter than the duration of the protection.
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M3 - Article
C2 - 1856488
AN - SCOPUS:0025734241
VL - 164
SP - 407
EP - 411
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -