Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: A controlled trial

Maryam Keshtkar-Jahromi, Hassan Argani, Mohammad Rahnavardi, Elham Mirchi, Shahnaz Atabak, Seied Ahmad Tara, Latif Gachkar, Azam Noori-Froothghe, Talat Mokhtari-Azad

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). Methods: 40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006-2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. ≥1:40), the serological response (i.e. ≥4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated. Results: KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination. Conclusions: Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs.

Original languageEnglish (US)
Pages (from-to)654-660
Number of pages7
JournalAmerican Journal of Nephrology
Volume28
Issue number4
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Keywords

  • Antibody response
  • Azathioprine
  • Immunization
  • Influenza
  • Kidney transplant recipient
  • Mycophenolate mofetil
  • Vaccination

ASJC Scopus subject areas

  • Nephrology

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