Antibody response to hepatitis a immunization among human immunodeficiency virus-infected children and adolescents

George K. Siberry, Ryan J. Coller, Emily Henkle, Carolyn Kiefner, Mary Joyner, Jamie Rogers, Jennifer Chang, Nancy Hutton

Research output: Contribution to journalArticlepeer-review

Abstract

Seventy-one of 84 human immunodeficiency virus (HIV)-infected children [84.5% (95% confidence interval: 75 "91.5%)] were hepatitis A virus (HAV) seropositive after 2 doses of HAV vaccine. Higher CD4% and HIV suppression were significantly associated with increased HAV seropositivity rate. In multivariate analysis, CD4 ĝ‰¥25% and young age were independent predictors of HAV seropositivity. Of 7 children given a third HAV vaccine dose because of negative HAV antibody after 2 doses, 2 (29%) became seropositive.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalPediatric Infectious Disease Journal
Volume27
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • HIV infection
  • hepatitis A vaccine
  • immunization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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