Antibody-mediated protection against intracellular pathogens

Arturo Casadevall

doi:10.1016/S0966-842X(98)01208-6

Antibody-mediated protection against intracellular pathogens

Arturo Casadevall

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

The view that antibody-mediated protection is unimportant against intracellular pathogens is not supported by the literature. In fact, there is convincing evidence that antibody can protect against many important intracellular pathogens. The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate.

Original language	English (US)
Pages (from-to)	102-107
Number of pages	6
Journal	Trends in Microbiology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/S0966-842X(98)01208-6
State	Published - Mar 1 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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10.1016/S0966-842X(98)01208-6

Cite this

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title = "Antibody-mediated protection against intracellular pathogens",

abstract = "The view that antibody-mediated protection is unimportant against intracellular pathogens is not supported by the literature. In fact, there is convincing evidence that antibody can protect against many important intracellular pathogens. The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate.",

author = "Arturo Casadevall",

note = "Funding Information: I thank Drs Toby Eisenstein, George Deepe and Marcia Goldberg for critical reading of this manuscript and many valuable discussions, and acknowledge support from Public Health Service grants AI133774, AI13342, and HL59842 and a Burroughs Wellcome Fund Developmental Therapeutics Award. ",

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AU - Casadevall, Arturo

N1 - Funding Information: I thank Drs Toby Eisenstein, George Deepe and Marcia Goldberg for critical reading of this manuscript and many valuable discussions, and acknowledge support from Public Health Service grants AI133774, AI13342, and HL59842 and a Burroughs Wellcome Fund Developmental Therapeutics Award.

PY - 1998/3/1

Y1 - 1998/3/1

N2 - The view that antibody-mediated protection is unimportant against intracellular pathogens is not supported by the literature. In fact, there is convincing evidence that antibody can protect against many important intracellular pathogens. The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate.

AB - The view that antibody-mediated protection is unimportant against intracellular pathogens is not supported by the literature. In fact, there is convincing evidence that antibody can protect against many important intracellular pathogens. The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate.

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ER -

Antibody-mediated protection against intracellular pathogens

Abstract

ASJC Scopus subject areas

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