Antibody-dependent cellular cytotoxicity in patients with mycosis fungoides and sézary syndrome

Sucha O. Asbell, Nancy Gadol, Paul Saluk, Eric C. Vonderheid, Luther W. Brady

Research output: Contribution to journalArticlepeer-review

Abstract

An antibody-dependent cell-mediated cytotoxicity (ADCC) assay was utilized to measure null cell function in 37 patients with cutaneous lymphomas including mycosis fungoides (NM and Sezary syndrome. Five patients with psoriasis vulgaris were included as controls for benign dermatologic disease. Patients with MF, non-MF cutaneous lymphomas, and psoriasis had mean ADCC levels equal to or greater than control values, while patients with Sézary syndrome had significantly depressed levels (64% of control values). Although this study did not explain the reason for the depression, it indicated that the ADCC assay may prove useful as a prognostic tool and as an additional means of identifying Sezary syndrome.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume4
Issue number7-8
DOIs
StatePublished - 1978
Externally publishedYes

Keywords

  • Antibody-dependent cell-mediated cytotoxicity
  • Mycosis fungoides
  • Sezary syndrome

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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