Antibody and/or cell-mediated immunity, protective mechanisms in fungal disease: An ongoing dilemma or an unnecessary dispute?

A. Casadevall, A. Cassone, F. Bistoni, J. E. Cutler, W. Magliani, J. W. Murphy, L. Polonelli, L. Romani

Research output: Contribution to journalArticle

Abstract

Historically there has been controversy on the relative importance of antibody- and cell-mediated immune responses in the protection against fungal pathogens. The controversy was fuelled by the difficulties encountered in obtaining consistent results with polyclonal antibody experiments and I inducing long-lasting immune protection by vaccinations with induce stron cell-mediated responses. Recent studies indicate that both antibody- and cell-mediated immune responses can contribute to host protection against Candida albicans and C. neoformans. At the present time the major issue is not the relative importance of antibody- and cell-mediated immune responses but rather, the mechanisms by which the two arms of the immune system function and cooperate.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalMedical Mycology, Supplement
Volume36
Issue number1
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Antibody
  • Candida albicans
  • Cell-mediated immunity
  • Cryptococcus neoformans
  • Humoral immunity
  • T cell
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology

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  • Cite this

    Casadevall, A., Cassone, A., Bistoni, F., Cutler, J. E., Magliani, W., Murphy, J. W., Polonelli, L., & Romani, L. (1998). Antibody and/or cell-mediated immunity, protective mechanisms in fungal disease: An ongoing dilemma or an unnecessary dispute? Medical Mycology, Supplement, 36(1), 95-105.