Antibodies to Toxoplasma gondii in individuals with mania

Faith Dickerson, Cassie Stallings, Andrea Origoni, Crystal Vaughan, Emily Katsafanas, Sunil Khushalani, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Objectives: Increased rates of infection with Toxoplasma gondii have been found in individuals with schizophrenia as compared to control groups but this issue has not been studied in mania. Methods: We measured immunoglobulin G (IgG) and IgM class antibodies to T. gondii in 57 individuals with mania who were assessed at up to three time-points. We also measured these antibodies in 743 individuals in other psychiatric groups and in 314 non-psychiatric controls. T. gondii antibody levels were compared among groups by multivariate analyses. IgG class and IgM class antibodies to cytomegalovirus were also measured in the same samples. T. gondii antibody levels were also compared over time in the mania group. Results: The mania group had a significantly elevated level of IgM antibodies to T. gondii as compared to the control individuals without a psychiatric diagnosis [odds ratio (OR) = 2.33, p 

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalBipolar Disorders
Volume16
Issue number2
DOIs
StatePublished - Mar 2014

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Toxoplasma
Bipolar Disorder
Immunoglobulin Isotypes
Immunoglobulin M
Antibodies
Immunoglobulin G
Toxoplasmosis
Cytomegalovirus
Mental Disorders
Psychiatry
Schizophrenia
Multivariate Analysis
Odds Ratio
Control Groups

Keywords

  • Bipolar disorder
  • Infection
  • Mania
  • Parasite
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Dickerson, F., Stallings, C., Origoni, A., Vaughan, C., Katsafanas, E., Khushalani, S., & Yolken, R. H. (2014). Antibodies to Toxoplasma gondii in individuals with mania. Bipolar Disorders, 16(2), 129-136. https://doi.org/10.1111/bdi.12123

Antibodies to Toxoplasma gondii in individuals with mania. / Dickerson, Faith; Stallings, Cassie; Origoni, Andrea; Vaughan, Crystal; Katsafanas, Emily; Khushalani, Sunil; Yolken, Robert H.

In: Bipolar Disorders, Vol. 16, No. 2, 03.2014, p. 129-136.

Research output: Contribution to journalArticle

Dickerson, F, Stallings, C, Origoni, A, Vaughan, C, Katsafanas, E, Khushalani, S & Yolken, RH 2014, 'Antibodies to Toxoplasma gondii in individuals with mania', Bipolar Disorders, vol. 16, no. 2, pp. 129-136. https://doi.org/10.1111/bdi.12123
Dickerson F, Stallings C, Origoni A, Vaughan C, Katsafanas E, Khushalani S et al. Antibodies to Toxoplasma gondii in individuals with mania. Bipolar Disorders. 2014 Mar;16(2):129-136. https://doi.org/10.1111/bdi.12123
Dickerson, Faith ; Stallings, Cassie ; Origoni, Andrea ; Vaughan, Crystal ; Katsafanas, Emily ; Khushalani, Sunil ; Yolken, Robert H. / Antibodies to Toxoplasma gondii in individuals with mania. In: Bipolar Disorders. 2014 ; Vol. 16, No. 2. pp. 129-136.
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