Antibodies to ICAM-1 Protect Kidneys in Severe Ischemic Reperfusion Injury

Hamid Rabb, C. C. Mendiola, S. R. Saba, J. R. Dietz, C. W. Smith, J. V. Bonventre, G. Ramirez

Research output: Contribution to journalArticle

Abstract

ICAM-1 has been implicated in the pathophysiology of ischemic-reperfusion injury in a number of organs, but its role in mediating severe ischemic-reperfusion injury in the kidney has not been extensively studied. Uninephrectomized Sprague Dawley rats were pretreated with either control monoclonal antibody (mAb) or mAb to ICAM-1 and subjected to 60 min of renal artery occlusion. The serum creatinine, complete blood count and kidney histo-pathological damage scores (PDS) (Scale:0-4) were assessed prior to and 24 hours after ischemia. Mean serum creatinine (mg/dl) 24 hours after ischemia was significantly decreased in the anti-ICAM-1 group (1.38 ± 0.23, p

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume211
Issue number1
DOIs
StatePublished - Jun 6 1995
Externally publishedYes

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Intercellular Adhesion Molecule-1
Reperfusion Injury
Kidney
Antibodies
Creatinine
Ischemia
Monoclonal Antibodies
Blood Cell Count
Renal Artery
Serum
Sprague Dawley Rats
Rats
Blood

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

Rabb, H., Mendiola, C. C., Saba, S. R., Dietz, J. R., Smith, C. W., Bonventre, J. V., & Ramirez, G. (1995). Antibodies to ICAM-1 Protect Kidneys in Severe Ischemic Reperfusion Injury. Biochemical and Biophysical Research Communications, 211(1), 67-73. https://doi.org/10.1006/bbrc.1995.1779

Antibodies to ICAM-1 Protect Kidneys in Severe Ischemic Reperfusion Injury. / Rabb, Hamid; Mendiola, C. C.; Saba, S. R.; Dietz, J. R.; Smith, C. W.; Bonventre, J. V.; Ramirez, G.

In: Biochemical and Biophysical Research Communications, Vol. 211, No. 1, 06.06.1995, p. 67-73.

Research output: Contribution to journalArticle

Rabb, H, Mendiola, CC, Saba, SR, Dietz, JR, Smith, CW, Bonventre, JV & Ramirez, G 1995, 'Antibodies to ICAM-1 Protect Kidneys in Severe Ischemic Reperfusion Injury', Biochemical and Biophysical Research Communications, vol. 211, no. 1, pp. 67-73. https://doi.org/10.1006/bbrc.1995.1779
Rabb, Hamid ; Mendiola, C. C. ; Saba, S. R. ; Dietz, J. R. ; Smith, C. W. ; Bonventre, J. V. ; Ramirez, G. / Antibodies to ICAM-1 Protect Kidneys in Severe Ischemic Reperfusion Injury. In: Biochemical and Biophysical Research Communications. 1995 ; Vol. 211, No. 1. pp. 67-73.
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