Abstract
Renal transplant rejection is accompanied frequently by high titers of antibodies in the circulation and deposits of antibodies in the graft vessels. Analysis of circulating antibodies have revealed a multiplicity of classes and specificities. Antibodies with reactivities to lymphocytes (possibly HLA-DR or LB), monocytes, granulocytes (AYD), and endothelial (E) cells have been detected singly or in various combinations. The production of antibodies to antigens unrelated to the donor kidney may also be stimulated. Thus, renal transplantation may trigger a polyclonal antibody response only a part of which may participate actively in graft rejection. We have reported that eluates from two kidneys contained only antibodies to endothelial-monocyte (EM) antigens, even though antibodies to a wide range of antigens were present in the circulation. Therefore, the determination of those antibodies deposited in rejecting grafts may provide more accurate information about the antibodies participating in graft rejection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1547-1550 |
| Number of pages | 4 |
| Journal | Transplantation Proceedings |
| Volume | 13 |
| Issue number | 3 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Transplantation
Cite this
Antibodies to endothelial antigens in eluates of 88 human kidneys : Correlation with graft survival and presence of T- and B-cell antibodies. / Baldwin, W. M.; Soulillou, J. P.; Claas, F. H J; Peyrat, M. A.; van Es, L. A.; van Rood, J. J.
In: Transplantation Proceedings, Vol. 13, No. 3, 1981, p. 1547-1550.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibodies to endothelial antigens in eluates of 88 human kidneys
T2 - Correlation with graft survival and presence of T- and B-cell antibodies
AU - Baldwin, W. M.
AU - Soulillou, J. P.
AU - Claas, F. H J
AU - Peyrat, M. A.
AU - van Es, L. A.
AU - van Rood, J. J.
PY - 1981
Y1 - 1981
N2 - Renal transplant rejection is accompanied frequently by high titers of antibodies in the circulation and deposits of antibodies in the graft vessels. Analysis of circulating antibodies have revealed a multiplicity of classes and specificities. Antibodies with reactivities to lymphocytes (possibly HLA-DR or LB), monocytes, granulocytes (AYD), and endothelial (E) cells have been detected singly or in various combinations. The production of antibodies to antigens unrelated to the donor kidney may also be stimulated. Thus, renal transplantation may trigger a polyclonal antibody response only a part of which may participate actively in graft rejection. We have reported that eluates from two kidneys contained only antibodies to endothelial-monocyte (EM) antigens, even though antibodies to a wide range of antigens were present in the circulation. Therefore, the determination of those antibodies deposited in rejecting grafts may provide more accurate information about the antibodies participating in graft rejection.
AB - Renal transplant rejection is accompanied frequently by high titers of antibodies in the circulation and deposits of antibodies in the graft vessels. Analysis of circulating antibodies have revealed a multiplicity of classes and specificities. Antibodies with reactivities to lymphocytes (possibly HLA-DR or LB), monocytes, granulocytes (AYD), and endothelial (E) cells have been detected singly or in various combinations. The production of antibodies to antigens unrelated to the donor kidney may also be stimulated. Thus, renal transplantation may trigger a polyclonal antibody response only a part of which may participate actively in graft rejection. We have reported that eluates from two kidneys contained only antibodies to endothelial-monocyte (EM) antigens, even though antibodies to a wide range of antigens were present in the circulation. Therefore, the determination of those antibodies deposited in rejecting grafts may provide more accurate information about the antibodies participating in graft rejection.
UR - http://www.scopus.com/inward/record.url?scp=0019870341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019870341&partnerID=8YFLogxK
M3 - Article
C2 - 7029812
AN - SCOPUS:0019870341
VL - 13
SP - 1547
EP - 1550
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 3
ER -