Antibodies reacting to simian virus 40 T antigen in human sera

K. V. Shah, R. W. Daniel, G. Murphy

Research output: Contribution to journalArticlepeer-review

Abstract

Antibodies reacting to simian virus 40 (SV40) T antigen in fluorescent antibody tests were detected in 13 successive serum specimens of a young renal transplant recipient. These sera had minimal or undetectable levels of SV40 neutralizing antibodies but high titers of antibodies to B.K. virus, an SV40 related papovavirus infection of man. There was no clinical or laboratory evidence that the patient had a tumor. In addition, SV40 T antigen reactive antibodies were found in the sera of 2 of 30 Maryland children with B.K. hemagglutination inhibition antibody titers of 1:640 or above but in none of 75 children with titers ranging from <1:20 to 1:320. The 2 SV40 T antigen reactive sera were negative for SV40 neutralizing antibodies. Hamster sera containing only SV40 T antibodies specifically stained the nuclei of B.K. virus infected vero cells. These data suggest that the observed reaction of human sera with SV40 T antigen is the result of a minor antigenic relationship between T antigens of SV40 and B.K. virus.

Original languageEnglish (US)
Pages (from-to)687-690
Number of pages4
JournalJournal of the National Cancer Institute
Volume51
Issue number2
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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