Antibodies produced in response to Cryptococcus neoformans pulmonary infection in mice have characteristics of nonprotective antibodies

Oscar Zaragoza, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review

Abstract

Murine cryptocococcal pulmonary infection elicited serum immunoglobulin M (IgM) and IgG to the capsular polysaccharide, but only IgG stained yeast cells in alveoli. Both isotypes produced punctuate immunofluorescence patterns on yeast cells like those of nonprotective antibodies. The difficulties involved in associating humoral immunity with protection in murine cryptocococcal infection could reflect nonprotective antibody responses.

Original languageEnglish (US)
Pages (from-to)4271-4274
Number of pages4
JournalInfection and immunity
Volume72
Issue number7
DOIs
StatePublished - Jul 2004
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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