TY - JOUR
T1 - Antibodies in urine of chimpanzees with chronic adenoviral viruria
AU - Shavrina Asher, Ludmila V.
AU - Asher, David M.
AU - Shah, Keerti V.
AU - Amyx, Herbert L.
AU - Gibbs, Clarence J.
AU - Gajdusek, D. Carleton
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1978
Y1 - 1978
N2 - Many chimpanzees have naturally occurring chronic intermittent viruria with an adenovirus of a new type called Pan 11. Small amounts of neutralizing antibodies to Pan 11 adenovirus were found in the urine of chimpanzees. Urinary antibodies to adenovirus were mainly of the immunoglobulin G (IgG) class with some IgA antibodies also present. There was no neutralizing activity in urine against another adenovirus, Pan 9, which has been isolated from lymph nodes, but not from urine, of chimpanzees; however, sera of all chimpanzees had neutralizing antibodies to Pan 9 virus, some with titers similar to those of antibodies against Pan 11 virus. Antibodies reacting with simian cytomegalovirus by indirect immunofluorescence were found in sera of all chimpanzees tested and in 2 of 6 urines. There was no correlation between levels of antiviral IgG antibodies in serum and urine by immunofluorescence. These findings suggest that both IgG and IgA antibodies may be locally produced in response to viral infection of the urinary tract in primates.
AB - Many chimpanzees have naturally occurring chronic intermittent viruria with an adenovirus of a new type called Pan 11. Small amounts of neutralizing antibodies to Pan 11 adenovirus were found in the urine of chimpanzees. Urinary antibodies to adenovirus were mainly of the immunoglobulin G (IgG) class with some IgA antibodies also present. There was no neutralizing activity in urine against another adenovirus, Pan 9, which has been isolated from lymph nodes, but not from urine, of chimpanzees; however, sera of all chimpanzees had neutralizing antibodies to Pan 9 virus, some with titers similar to those of antibodies against Pan 11 virus. Antibodies reacting with simian cytomegalovirus by indirect immunofluorescence were found in sera of all chimpanzees tested and in 2 of 6 urines. There was no correlation between levels of antiviral IgG antibodies in serum and urine by immunofluorescence. These findings suggest that both IgG and IgA antibodies may be locally produced in response to viral infection of the urinary tract in primates.
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U2 - 10.1128/iai.21.2.458-461.1978
DO - 10.1128/iai.21.2.458-461.1978
M3 - Article
C2 - 211084
AN - SCOPUS:0018138309
VL - 21
SP - 458
EP - 461
JO - Advances in Water Resources
JF - Advances in Water Resources
SN - 0309-1708
IS - 2
ER -