Antibodies against fetal brain in sera of mothers with autistic children

Harvey S. Singer, Christina M. Morris, Colin D. Gause, Pam K. Gillin, Stephen Crawford, Andrew W. Zimmerman

Research output: Contribution to journalArticle

Abstract

Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalJournal of Neuroimmunology
Volume194
Issue number1-2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Autistic disorder
  • Autoimmunity
  • BDNF
  • GFAP
  • Maternal antibodies
  • Myelin basic protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Singer, H. S., Morris, C. M., Gause, C. D., Gillin, P. K., Crawford, S., & Zimmerman, A. W. (2008). Antibodies against fetal brain in sera of mothers with autistic children. Journal of Neuroimmunology, 194(1-2), 165-172. https://doi.org/10.1016/j.jneuroim.2007.11.004