Antibiotics for the treatment of dysentery in children

Beatrix S. Traa, Christa L. Fischer Walker, Melinda Kay Munos, Robert E Black

Research output: Contribution to journalArticle

Abstract

Background: Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years. Methods: We reviewed all literature reporting the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. We used a standardized abstraction and grading format and performed meta-analyses to determine the effect of treatment with these antibiotics on rates of treatment failure, bacteriological failure and bacteriological relapse. The CHERG Standard Rules were applied to determine the final effect of treatment with these antibiotics on diarrhoea mortality. Results: Eight papers were selected for abstraction. Treatment with ciprofloxacin, ceftriaxone or pivmecillinam resulted in a cure rate of

Original languageEnglish (US)
JournalInternational Journal of Epidemiology
Volume39
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 1 2010

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Dysentery
Amdinocillin Pivoxil
Ceftriaxone
Anti-Bacterial Agents
Ciprofloxacin
Therapeutics
Treatment Failure
Developing Countries
Meta-Analysis
Diarrhea
Recurrence
Mortality

Keywords

  • Ceftriaxone
  • Diarrhoea
  • Dysentery
  • Iprofloxacin
  • Morbidity
  • Mortality
  • Pivmecillinam
  • Treatment

ASJC Scopus subject areas

  • Epidemiology

Cite this

Antibiotics for the treatment of dysentery in children. / Traa, Beatrix S.; Fischer Walker, Christa L.; Munos, Melinda Kay; Black, Robert E.

In: International Journal of Epidemiology, Vol. 39, No. SUPPL. 1, 01.04.2010.

Research output: Contribution to journalArticle

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