Antibiotics and appendicitis in the pediatric population

An American Pediatric Surgical Association Outcomes and Clinical Trials Committee Systematic Review

Steven L. Lee, Saleem Islam, Laura D. Cassidy, Fizan Abdullah, Marjorie J. Arca

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the study was to review evidence-based data regarding the use of antibiotics for the treatment of appendicitis in children. Data Source: Data were obtained from PubMed, MEDLINE, and citation review. Study Selection: We conducted a literature search using "appendicitis" combined with "antibiotics" with children as the target patient population. Studies were selected based on relevance for the following questions:What perioperative antibiotics should be used for pediatric patients with nonperforated appendicitis?For patients with perforated appendicitis treated with appendectomy:What perioperative intravenous antibiotics should be used?How long should perioperative intravenous antibiotics be used?Should oral antibiotics be used?For patients with perforated appendicitis treated with initial nonoperative management, what antibiotics should be used in the initial management? Results: Children with nonperforated appendicitis should receive preoperative, broad-spectrum antibiotics. In children with perforated appendicitis who had undergone appendectomy, intravenous antibiotic duration should be based on clinical criteria. Furthermore, broad-spectrum, single, or double agent therapy is as equally efficacious as but is more cost-effective than triple agent therapy. If intravenous antibiotics are administered for less than 5 days, oral antibiotics should be administered for a total antibiotic course of 7 days. For children with perforated appendicitis who did not initially undergo an appendectomy, the duration of broad-spectrum, intravenous antibiotics should be based on clinical symptoms. Conclusions: Current evidence supports the use of guidelines as described above for antibiotic therapy in children with acute and perforated appendicitis.

Original languageEnglish (US)
Pages (from-to)2181-2185
Number of pages5
JournalJournal of Pediatric Surgery
Volume45
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Appendicitis
Advisory Committees
Clinical Trials
Pediatrics
Anti-Bacterial Agents
Population
Appendectomy
Health Services Needs and Demand
Information Storage and Retrieval
Therapeutics
PubMed
MEDLINE

Keywords

  • Antibiotics
  • Appendicitis
  • Pediatric
  • Perforated appendicitis

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Antibiotics and appendicitis in the pediatric population : An American Pediatric Surgical Association Outcomes and Clinical Trials Committee Systematic Review. / Lee, Steven L.; Islam, Saleem; Cassidy, Laura D.; Abdullah, Fizan; Arca, Marjorie J.

In: Journal of Pediatric Surgery, Vol. 45, No. 11, 11.2010, p. 2181-2185.

Research output: Contribution to journalArticle

Lee, Steven L. ; Islam, Saleem ; Cassidy, Laura D. ; Abdullah, Fizan ; Arca, Marjorie J. / Antibiotics and appendicitis in the pediatric population : An American Pediatric Surgical Association Outcomes and Clinical Trials Committee Systematic Review. In: Journal of Pediatric Surgery. 2010 ; Vol. 45, No. 11. pp. 2181-2185.
@article{32e4a024a6044750aee4588e2b8840a4,
title = "Antibiotics and appendicitis in the pediatric population: An American Pediatric Surgical Association Outcomes and Clinical Trials Committee Systematic Review",
abstract = "Objective: The aim of the study was to review evidence-based data regarding the use of antibiotics for the treatment of appendicitis in children. Data Source: Data were obtained from PubMed, MEDLINE, and citation review. Study Selection: We conducted a literature search using {"}appendicitis{"} combined with {"}antibiotics{"} with children as the target patient population. Studies were selected based on relevance for the following questions:What perioperative antibiotics should be used for pediatric patients with nonperforated appendicitis?For patients with perforated appendicitis treated with appendectomy:What perioperative intravenous antibiotics should be used?How long should perioperative intravenous antibiotics be used?Should oral antibiotics be used?For patients with perforated appendicitis treated with initial nonoperative management, what antibiotics should be used in the initial management? Results: Children with nonperforated appendicitis should receive preoperative, broad-spectrum antibiotics. In children with perforated appendicitis who had undergone appendectomy, intravenous antibiotic duration should be based on clinical criteria. Furthermore, broad-spectrum, single, or double agent therapy is as equally efficacious as but is more cost-effective than triple agent therapy. If intravenous antibiotics are administered for less than 5 days, oral antibiotics should be administered for a total antibiotic course of 7 days. For children with perforated appendicitis who did not initially undergo an appendectomy, the duration of broad-spectrum, intravenous antibiotics should be based on clinical symptoms. Conclusions: Current evidence supports the use of guidelines as described above for antibiotic therapy in children with acute and perforated appendicitis.",
keywords = "Antibiotics, Appendicitis, Pediatric, Perforated appendicitis",
author = "Lee, {Steven L.} and Saleem Islam and Cassidy, {Laura D.} and Fizan Abdullah and Arca, {Marjorie J.}",
year = "2010",
month = "11",
doi = "10.1016/j.jpedsurg.2010.06.038",
language = "English (US)",
volume = "45",
pages = "2181--2185",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "11",

}

TY - JOUR

T1 - Antibiotics and appendicitis in the pediatric population

T2 - An American Pediatric Surgical Association Outcomes and Clinical Trials Committee Systematic Review

AU - Lee, Steven L.

AU - Islam, Saleem

AU - Cassidy, Laura D.

AU - Abdullah, Fizan

AU - Arca, Marjorie J.

PY - 2010/11

Y1 - 2010/11

N2 - Objective: The aim of the study was to review evidence-based data regarding the use of antibiotics for the treatment of appendicitis in children. Data Source: Data were obtained from PubMed, MEDLINE, and citation review. Study Selection: We conducted a literature search using "appendicitis" combined with "antibiotics" with children as the target patient population. Studies were selected based on relevance for the following questions:What perioperative antibiotics should be used for pediatric patients with nonperforated appendicitis?For patients with perforated appendicitis treated with appendectomy:What perioperative intravenous antibiotics should be used?How long should perioperative intravenous antibiotics be used?Should oral antibiotics be used?For patients with perforated appendicitis treated with initial nonoperative management, what antibiotics should be used in the initial management? Results: Children with nonperforated appendicitis should receive preoperative, broad-spectrum antibiotics. In children with perforated appendicitis who had undergone appendectomy, intravenous antibiotic duration should be based on clinical criteria. Furthermore, broad-spectrum, single, or double agent therapy is as equally efficacious as but is more cost-effective than triple agent therapy. If intravenous antibiotics are administered for less than 5 days, oral antibiotics should be administered for a total antibiotic course of 7 days. For children with perforated appendicitis who did not initially undergo an appendectomy, the duration of broad-spectrum, intravenous antibiotics should be based on clinical symptoms. Conclusions: Current evidence supports the use of guidelines as described above for antibiotic therapy in children with acute and perforated appendicitis.

AB - Objective: The aim of the study was to review evidence-based data regarding the use of antibiotics for the treatment of appendicitis in children. Data Source: Data were obtained from PubMed, MEDLINE, and citation review. Study Selection: We conducted a literature search using "appendicitis" combined with "antibiotics" with children as the target patient population. Studies were selected based on relevance for the following questions:What perioperative antibiotics should be used for pediatric patients with nonperforated appendicitis?For patients with perforated appendicitis treated with appendectomy:What perioperative intravenous antibiotics should be used?How long should perioperative intravenous antibiotics be used?Should oral antibiotics be used?For patients with perforated appendicitis treated with initial nonoperative management, what antibiotics should be used in the initial management? Results: Children with nonperforated appendicitis should receive preoperative, broad-spectrum antibiotics. In children with perforated appendicitis who had undergone appendectomy, intravenous antibiotic duration should be based on clinical criteria. Furthermore, broad-spectrum, single, or double agent therapy is as equally efficacious as but is more cost-effective than triple agent therapy. If intravenous antibiotics are administered for less than 5 days, oral antibiotics should be administered for a total antibiotic course of 7 days. For children with perforated appendicitis who did not initially undergo an appendectomy, the duration of broad-spectrum, intravenous antibiotics should be based on clinical symptoms. Conclusions: Current evidence supports the use of guidelines as described above for antibiotic therapy in children with acute and perforated appendicitis.

KW - Antibiotics

KW - Appendicitis

KW - Pediatric

KW - Perforated appendicitis

UR - http://www.scopus.com/inward/record.url?scp=78049460433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049460433&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2010.06.038

DO - 10.1016/j.jpedsurg.2010.06.038

M3 - Article

VL - 45

SP - 2181

EP - 2185

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 11

ER -