Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children

Daniel R. Feikin, Mollie Davis, Okey C. Nwanyanwu, Peter N. Kazembe, Lawrence M. Barat, Avril Wasas, Peter B. Bloland, Charles Ziba, Thora Capper, Robin E. Huebner, Ben Schwartz, Keith P. Klugman, Scott F. Dowell

Research output: Contribution to journalArticlepeer-review

Abstract

Nasopharyngeal swabs were taken from 906 Malawian children <5 years old visiting rural health clinics. Pneumococcal colonization was high, 84% among all children, and occurred early, 65% of it in children <3 months old. Among pneumococcal isolates 46% were nonsusceptible to trimethoprim-sulfamethoxazole, and 21% were nonsusceptible to penicillin. Trimethoprim-sulfamethoxazole use in the previous month was a risk factor for trimethoprim-sulfamethoxazole and penicillin non-susceptibility. Forty-three percent of isolates were serotypes included in the 7-valent pneumococcal conjugate vaccine, and 37% were vaccine-related serotypes, particularly 6A and 19A.

Original languageEnglish (US)
Pages (from-to)564-567
Number of pages4
JournalPediatric Infectious Disease Journal
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Keywords

  • Antibiotic resistance
  • Malawi
  • Pneumococcus
  • Serotypes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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