Antibiotic levels in infected and sterile subcutaneous abscesses in mice

K. A. Joiner, B. R. Lowe, J. L. Dzink, J. G. Bartlett

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetic properties of 10 antimicrobial agents were examined in sterile and infected encapsulated subcutaneous abscesses in mice. The inoculum for sterile abscesses was autoclaved cecal contents; that for infected abscesses was autoclaved cecal contents combined with Bacteroides fragilis. The antimicrobial agents examined were rosaramicin, clindamycin, chloramphenicol, metronidazole, and six 0-lactam antibiotics. All antimicrobial agents entered abscesses, produced peak levels of biological activity that were somewhat delayed in comparison to serum levels, and were present in negligible levels 8 hr after administration. The highest concentration in abscesses was achieved with rosaramicin and clindamycin, with peak levels of 43%-63% of the peak serum level. Peak levels of other antimicrobial agents in sterile abscesses were 13%-27(Vo of the peak serum level. Levels of biologically active drug were significantly lower in infected abscesses than in sterile abscesses for antimicrobial agents that are inactivated by B. fragilis fi-lactamase.

Original languageEnglish (US)
Pages (from-to)487-494
Number of pages8
JournalJournal of Infectious Diseases
Volume143
Issue number3
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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