ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN

G. D. Rifkin, F. R. Fekety, J. Silva, R. B. Sack

Research output: Contribution to journalArticle

Abstract

A toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio cholerœ toxins. These characteristics were identical to those of a toxin implicated in the ætiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.

Original languageEnglish (US)
Pages (from-to)1103-1106
Number of pages4
JournalThe Lancet
Volume310
Issue number8048
DOIs
StatePublished - Nov 26 1977

ASJC Scopus subject areas

  • Medicine(all)

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