Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

Mohamed H. Khattab, Ariel E. Marciscano, Simon S. Lo, Michael Lim, John J. Laterra, Lawrence R. Kleinberg, Kristin J. Redmond

Research output: Contribution to journalReview articlepeer-review

Abstract

We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

Original languageEnglish (US)
Article number431819
JournalCase Reports in Oncological Medicine
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature'. Together they form a unique fingerprint.

Cite this