Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

Mohamed H. Khattab; Ariel E. Marciscano; Simon S. Lo; Michael Lim; John J. Laterra; Lawrence R. Kleinberg; Kristin J. Redmond

doi:10.1155/2015/431819

Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

Mohamed H. Khattab, Ariel E. Marciscano, Simon S. Lo, Michael Lim, John J. Laterra, Lawrence R. Kleinberg, Kristin J. Redmond

School of Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

Original language	English (US)
Article number	431819
Journal	Case Reports in Oncological Medicine
Volume	2015
DOIs	https://doi.org/10.1155/2015/431819
State	Published - 2015

ASJC Scopus subject areas

Oncology

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title = "Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature",

abstract = "We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.",

author = "Khattab, {Mohamed H.} and Marciscano, {Ariel E.} and Lo, {Simon S.} and Michael Lim and Laterra, {John J.} and Kleinberg, {Lawrence R.} and Redmond, {Kristin J.}",

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journal = "Case Reports in Oncological Medicine",

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T2 - A Case Report and Review of the Literature

AU - Khattab, Mohamed H.

AU - Marciscano, Ariel E.

AU - Lo, Simon S.

AU - Lim, Michael

AU - Laterra, John J.

AU - Kleinberg, Lawrence R.

AU - Redmond, Kristin J.

PY - 2015

Y1 - 2015

N2 - We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

AB - We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

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DO - 10.1155/2015/431819

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AN - SCOPUS:84983519238

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VL - 2015

JO - Case Reports in Oncological Medicine

JF - Case Reports in Oncological Medicine

M1 - 431819

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Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

Abstract

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