Anti-Tumour activity of Ruta Graveolens extract

Preethi Korangath, Girija Kuttan, Ramadasan Kuttan

Research output: Contribution to journalArticle

Abstract

An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100 = 16mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume7
Issue number3
StatePublished - 2006
Externally publishedYes

Fingerprint

Ruta
Ascites
Neoplasms
Hydroxyl Radical
Lipid Peroxidation
Lymphoma
Carcinoma
Cell Culture Techniques

Keywords

  • Anti tumour drugs
  • Antioxidants
  • Herbal drugs
  • Prooxidants
  • Ruta graveolens

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Anti-Tumour activity of Ruta Graveolens extract. / Korangath, Preethi; Kuttan, Girija; Kuttan, Ramadasan.

In: Asian Pacific Journal of Cancer Prevention, Vol. 7, No. 3, 2006, p. 439-443.

Research output: Contribution to journalArticle

Korangath, Preethi ; Kuttan, Girija ; Kuttan, Ramadasan. / Anti-Tumour activity of Ruta Graveolens extract. In: Asian Pacific Journal of Cancer Prevention. 2006 ; Vol. 7, No. 3. pp. 439-443.
@article{2e7c796ef9f94f1ba353d8525e2c6726,
title = "Anti-Tumour activity of Ruta Graveolens extract",
abstract = "An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100 = 16mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.",
keywords = "Anti tumour drugs, Antioxidants, Herbal drugs, Prooxidants, Ruta graveolens",
author = "Preethi Korangath and Girija Kuttan and Ramadasan Kuttan",
year = "2006",
language = "English (US)",
volume = "7",
pages = "439--443",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "3",

}

TY - JOUR

T1 - Anti-Tumour activity of Ruta Graveolens extract

AU - Korangath, Preethi

AU - Kuttan, Girija

AU - Kuttan, Ramadasan

PY - 2006

Y1 - 2006

N2 - An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100 = 16mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.

AB - An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100 = 16mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.

KW - Anti tumour drugs

KW - Antioxidants

KW - Herbal drugs

KW - Prooxidants

KW - Ruta graveolens

UR - http://www.scopus.com/inward/record.url?scp=39049176427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39049176427&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 439

EP - 443

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 3

ER -