Anti-Tumour activity of Ruta Graveolens extract

K. C. Preethi, Girija Kuttan, Ramadasan Kuttan

Research output: Contribution to journalArticle

Abstract

An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100 = 16mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume7
Issue number3
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • Anti tumour drugs
  • Antioxidants
  • Herbal drugs
  • Prooxidants
  • Ruta graveolens

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Fingerprint Dive into the research topics of 'Anti-Tumour activity of Ruta Graveolens extract'. Together they form a unique fingerprint.

  • Cite this