Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Claudia Sommer, Thies Lindenlaub, Philipp Teuteberg, Maria Schäfers, Thomas Hartung, Klaus V. Toyka

Research output: Contribution to journalArticle

Abstract

We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalBrain research
Volume913
Issue number1
DOIs
StatePublished - Sep 14 2001
Externally publishedYes

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Keywords

  • Cytokines
  • Hyperalgesia
  • Neuropathy
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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