Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Claudia Sommer; Thies Lindenlaub; Philipp Teuteberg; Maria Schäfers; Thomas Hartung; Klaus V. Toyka

doi:10.1016/S0006-8993(01)02743-3

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Claudia Sommer, Thies Lindenlaub, Philipp Teuteberg, Maria Schäfers, Thomas Hartung, Klaus V. Toyka

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	Brain research
Volume	913
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(01)02743-3
State	Published - Sep 14 2001
Externally published	Yes

Keywords

Cytokines
Hyperalgesia
Neuropathy
Tumor necrosis factor-α

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(01)02743-3

Cite this

@article{61cbfe377a56490cad14e6f2a8601477,

title = "Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy",

abstract = "We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.",

keywords = "Cytokines, Hyperalgesia, Neuropathy, Tumor necrosis factor-α",

author = "Claudia Sommer and Thies Lindenlaub and Philipp Teuteberg and Maria Sch{\"a}fers and Thomas Hartung and Toyka, {Klaus V.}",

note = "Funding Information: We would like to thank B. Dekant and L. Biko for technical assistance. Supported by Deutsche Forschungsgemeinschaft SFB 353.",

year = "2001",

month = sep,

day = "14",

doi = "10.1016/S0006-8993(01)02743-3",

language = "English (US)",

volume = "913",

pages = "86--89",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

AU - Sommer, Claudia

AU - Lindenlaub, Thies

AU - Teuteberg, Philipp

AU - Schäfers, Maria

AU - Hartung, Thomas

AU - Toyka, Klaus V.

N1 - Funding Information: We would like to thank B. Dekant and L. Biko for technical assistance. Supported by Deutsche Forschungsgemeinschaft SFB 353.

PY - 2001/9/14

Y1 - 2001/9/14

N2 - We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

AB - We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

KW - Cytokines

KW - Hyperalgesia

KW - Neuropathy

KW - Tumor necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=0035860577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035860577&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(01)02743-3

DO - 10.1016/S0006-8993(01)02743-3

M3 - Article

C2 - 11532251

AN - SCOPUS:0035860577

SN - 0006-8993

VL - 913

SP - 86

EP - 89

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this