Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Claudia Sommer; Thies Lindenlaub; Philipp Teuteberg; Maria Schäfers; Thomas Hartung; Klaus V. Toyka

doi:10.1016/S0006-8993(01)02743-3

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Claudia Sommer, Thies Lindenlaub, Philipp Teuteberg, Maria Schäfers, Thomas Hartung, Klaus V. Toyka

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	Brain research
Volume	913
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(01)02743-3
State	Published - Sep 14 2001
Externally published	Yes

Keywords

Cytokines
Hyperalgesia
Neuropathy
Tumor necrosis factor-α

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(01)02743-3

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title = "Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy",

abstract = "We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.",

keywords = "Cytokines, Hyperalgesia, Neuropathy, Tumor necrosis factor-α",

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note = "Funding Information: We would like to thank B. Dekant and L. Biko for technical assistance. Supported by Deutsche Forschungsgemeinschaft SFB 353.",

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AU - Sommer, Claudia

AU - Lindenlaub, Thies

AU - Teuteberg, Philipp

AU - Schäfers, Maria

AU - Hartung, Thomas

AU - Toyka, Klaus V.

N1 - Funding Information: We would like to thank B. Dekant and L. Biko for technical assistance. Supported by Deutsche Forschungsgemeinschaft SFB 353.

PY - 2001/9/14

Y1 - 2001/9/14

N2 - We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

AB - We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-α (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.

KW - Cytokines

KW - Hyperalgesia

KW - Neuropathy

KW - Tumor necrosis factor-α

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Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Abstract

Keywords

ASJC Scopus subject areas

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