Anti-tetanus toxoid antibodies in intravenous gamma globulin: An alternative to tetanus immune globulin

Darlene C. Lee, Howard M. Lederman

Research output: Contribution to journalArticle

Abstract

The levels of anti-tetanus toxoid IgG antibodies were measured in 29 lots of intravenous gamma globulin (IVIG). The antibody levels varied from 4 to 90 IU/mL (geometric mean, 18.6; 90% confidence interval, 9.7-35.7). The variation from manufacturer to manufacturer accounted for most of the observed differences among lots; there was relatively little variability among multiple lots from a single manufacturer. IVIG may be an acceptable alternative to horse or human tetanus immune globulin.

Original languageEnglish (US)
Pages (from-to)642-645
Number of pages4
JournalJournal of Infectious Diseases
Volume166
Issue number3
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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