Anti-tetanus toxoid antibodies in intravenous gamma globulin: An alternative to tetanus immune globulin

Darlene C. Lee; Howard M. Lederman

doi:10.1093/infdis/166.3.642

Anti-tetanus toxoid antibodies in intravenous gamma globulin: An alternative to tetanus immune globulin

Darlene C. Lee, Howard M. Lederman

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The levels of anti-tetanus toxoid IgG antibodies were measured in 29 lots of intravenous gamma globulin (IVIG). The antibody levels varied from 4 to 90 IU/mL (geometric mean, 18.6; 90% confidence interval, 9.7-35.7). The variation from manufacturer to manufacturer accounted for most of the observed differences among lots; there was relatively little variability among multiple lots from a single manufacturer. IVIG may be an acceptable alternative to horse or human tetanus immune globulin.

Original language	English (US)
Pages (from-to)	642-645
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	166
Issue number	3
DOIs	https://doi.org/10.1093/infdis/166.3.642
State	Published - Sep 1992

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/166.3.642

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abstract = "The levels of anti-tetanus toxoid IgG antibodies were measured in 29 lots of intravenous gamma globulin (IVIG). The antibody levels varied from 4 to 90 IU/mL (geometric mean, 18.6; 90% confidence interval, 9.7-35.7). The variation from manufacturer to manufacturer accounted for most of the observed differences among lots; there was relatively little variability among multiple lots from a single manufacturer. IVIG may be an acceptable alternative to horse or human tetanus immune globulin.",

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AB - The levels of anti-tetanus toxoid IgG antibodies were measured in 29 lots of intravenous gamma globulin (IVIG). The antibody levels varied from 4 to 90 IU/mL (geometric mean, 18.6; 90% confidence interval, 9.7-35.7). The variation from manufacturer to manufacturer accounted for most of the observed differences among lots; there was relatively little variability among multiple lots from a single manufacturer. IVIG may be an acceptable alternative to horse or human tetanus immune globulin.

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Anti-tetanus toxoid antibodies in intravenous gamma globulin: An alternative to tetanus immune globulin

Abstract

ASJC Scopus subject areas

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