Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments

C. M. Morris-Berry, M. Pollard, S. Gao, C. Thompson, H. S. Singer

Research output: Contribution to journalArticlepeer-review

Abstract

Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta- d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n = 44) or Tourette syndrome (n = 40) as compared to controls (n = 24). Anti-tubulin and D2 receptor antibodies assessed in serial samples from 12 PANDAS subjects obtained prior to a documented exacerbation, during the exacerbation (with or without a temporally associated streptococcal infection), and following the exacerbation, showed no evidence of antibody levels correlating with a clinical exacerbation. These data do not support hypotheses suggesting an autoimmune hypothesis in either TS or PANDAS.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalJournal of Neuroimmunology
Volume264
Issue number1-2
DOIs
StatePublished - 2013

Keywords

  • Anti-neuronal antibodies
  • D2 receptor
  • PANDAS
  • Single-point and longitudinal
  • Tourette syndrome
  • Tubulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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