Anti-sporozoite antibodies and immunity to malaria in a rural Gambian population

K. Marsh, R. H. Hayes, D. C. Carson, L. Otoo, F. Shenton, P. Byass, F. Zavala, B. M. Greenwood

Research output: Contribution to journalArticle

Abstract

A conserved repeated epitope, (NANP)3, of the circumsporozoite protein of Plasmodium falciparum has been identified previously as a putative target for artificially induced immunity to malaria. We examined die role of humoral responses to this epitope in acquired immunity to malaria in a rural African population. Seropositivity to (NANP)3 was slow to develop (9% positive in subjects aged 1-11 years; 88% in those of 30 years and above), and responses in younger subjects were transient. The poor response in younger subjects did not appear to be due to immunosuppression by concomitant blood stage para-si tization. The relationship between levels of anti-(NANP)3 antibodies and parasitemia changed from positive to negative with age. 126 subjects age 1-11 years were followed through an entire transmission season; those who were seropositive at the beginning ended the season with lower parasite rates (20% vs 59%) and experienced fewer episodes of clinical malaria (0 43 vs 0-67). However, the trend towards increasing susceptibility to clinical malaria in subjects entering the transmission season with lower levels of anti-(NANP)3 antibodies was modest, and combined cross-sectional and longitudinal data indicated that the humoral response to (NANP)3 did not play a major role in the development of inimunity to clinical malaria in the population we studied.

Original languageEnglish (US)
Pages (from-to)532-537
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume82
Issue number4
DOIs
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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