Anti-Onchocerca volvulus immunoglobulin subclass response in children from Sierra Leone

A. A. Gbakima, M. S. Ibrahim, Alan Leroy Scott

Research output: Contribution to journalArticle

Abstract

The humoral immune responses of a paediatric population of 224 children, 2-15 years of age, residing in an onchocerciasis endemic area of Sierra Leone, were studied to gain information that may be useful in the serodiagnosis of prepatent and low-level infections with Onchocerca volvulus. The antigen-specific levels of IgG and IgG4 were determined and evaluated in the context of the parasitological status of the child. Over 87% of the microfilaria-negative children had significant levels of antigen-specific antibodies against O. volvulus, suggesting that a large percentage of this paediatric population were harbouring prepatent or low-level infections. Over 60% of the children in the group that had detectable numbers of microfilariae in skin snips had elevated levels of O. volvulus-specific IgG4. In contrast, only 23% of the microfilaria-negative children had detectable IgG4 responses. The results presented here indicate that measures of O. volvulus-specific IgG4 may be a useful indicator of the parasitological status of children during the very early stages of onchocerciasis.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalScandinavian Journal of Immunology, Supplement
Volume36
Issue number11
StatePublished - 1992

Fingerprint

Sierra Leone
Onchocerca volvulus
Immunoglobulins
Immunoglobulin G
Microfilariae
Onchocerciasis
Pediatrics
Antigens
Serologic Tests
Humoral Immunity
Infection
Population
Skin
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Anti-Onchocerca volvulus immunoglobulin subclass response in children from Sierra Leone. / Gbakima, A. A.; Ibrahim, M. S.; Scott, Alan Leroy.

In: Scandinavian Journal of Immunology, Supplement, Vol. 36, No. 11, 1992, p. 53-56.

Research output: Contribution to journalArticle

@article{1ab9c4a3800c4cc18ab583066ffdf0c3,
title = "Anti-Onchocerca volvulus immunoglobulin subclass response in children from Sierra Leone",
abstract = "The humoral immune responses of a paediatric population of 224 children, 2-15 years of age, residing in an onchocerciasis endemic area of Sierra Leone, were studied to gain information that may be useful in the serodiagnosis of prepatent and low-level infections with Onchocerca volvulus. The antigen-specific levels of IgG and IgG4 were determined and evaluated in the context of the parasitological status of the child. Over 87{\%} of the microfilaria-negative children had significant levels of antigen-specific antibodies against O. volvulus, suggesting that a large percentage of this paediatric population were harbouring prepatent or low-level infections. Over 60{\%} of the children in the group that had detectable numbers of microfilariae in skin snips had elevated levels of O. volvulus-specific IgG4. In contrast, only 23{\%} of the microfilaria-negative children had detectable IgG4 responses. The results presented here indicate that measures of O. volvulus-specific IgG4 may be a useful indicator of the parasitological status of children during the very early stages of onchocerciasis.",
author = "Gbakima, {A. A.} and Ibrahim, {M. S.} and Scott, {Alan Leroy}",
year = "1992",
language = "English (US)",
volume = "36",
pages = "53--56",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Anti-Onchocerca volvulus immunoglobulin subclass response in children from Sierra Leone

AU - Gbakima, A. A.

AU - Ibrahim, M. S.

AU - Scott, Alan Leroy

PY - 1992

Y1 - 1992

N2 - The humoral immune responses of a paediatric population of 224 children, 2-15 years of age, residing in an onchocerciasis endemic area of Sierra Leone, were studied to gain information that may be useful in the serodiagnosis of prepatent and low-level infections with Onchocerca volvulus. The antigen-specific levels of IgG and IgG4 were determined and evaluated in the context of the parasitological status of the child. Over 87% of the microfilaria-negative children had significant levels of antigen-specific antibodies against O. volvulus, suggesting that a large percentage of this paediatric population were harbouring prepatent or low-level infections. Over 60% of the children in the group that had detectable numbers of microfilariae in skin snips had elevated levels of O. volvulus-specific IgG4. In contrast, only 23% of the microfilaria-negative children had detectable IgG4 responses. The results presented here indicate that measures of O. volvulus-specific IgG4 may be a useful indicator of the parasitological status of children during the very early stages of onchocerciasis.

AB - The humoral immune responses of a paediatric population of 224 children, 2-15 years of age, residing in an onchocerciasis endemic area of Sierra Leone, were studied to gain information that may be useful in the serodiagnosis of prepatent and low-level infections with Onchocerca volvulus. The antigen-specific levels of IgG and IgG4 were determined and evaluated in the context of the parasitological status of the child. Over 87% of the microfilaria-negative children had significant levels of antigen-specific antibodies against O. volvulus, suggesting that a large percentage of this paediatric population were harbouring prepatent or low-level infections. Over 60% of the children in the group that had detectable numbers of microfilariae in skin snips had elevated levels of O. volvulus-specific IgG4. In contrast, only 23% of the microfilaria-negative children had detectable IgG4 responses. The results presented here indicate that measures of O. volvulus-specific IgG4 may be a useful indicator of the parasitological status of children during the very early stages of onchocerciasis.

UR - http://www.scopus.com/inward/record.url?scp=0026437890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026437890&partnerID=8YFLogxK

M3 - Article

C2 - 1514051

AN - SCOPUS:0026437890

VL - 36

SP - 53

EP - 56

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 11

ER -