Anti-Müllerian hormone levels and cardiometabolic disturbances by weight status among men in the 1999 to 2004 national health and nutrition examination survey

Hind A. Beydoun, Sharmin Hossain, May A. Beydoun, Jordan Weiss, Alan B. Zonderman, Shaker M. Eid

Research output: Contribution to journalArticle

Abstract

Context: Serum anti-M üllerian hormone level (AMH) and body mass index may be jointly associated with cardiometabolic risk. Objectives: Examine the contribution ofAMHto cardiometabolic disturbances by weight status among US adult men. Design: Cross-sectional analysis using data from the 1999 to 2004 waves of the National Health and Nutrition Examination Survey. Setting: Multistage probability sampling of the noninstitutionalized US population. Participants: USmen aged$18 years. Final analytic sample sizes ranged from 517 to 1063 participants. Main Outcome and Exposure Measures: Cardiometabolic disturbances (metabolic syndrome and its components, insulin resistance, diabetes, and chronic inflammation) and AMH were obtained from trained staff and nurses in a mobile examination center or during in-home visits. Results: AMH was directly associated with insulin resistance among obese men [OR 1.08 (95% CI 1.00, 1.15); P = 0.046; N 5 146], whereas AMH was inversely associated with waist circumference (WC) among obese men [OR 0.95 (95% CI 0.91, 0.99); P = 0.049; N 5 146]. An inverse relationship was also observed between categorical AMH and diabetes status [medium vs low AMH; OR 0.19 (95% CI 0.043, 0.84); P = 0.030; N 5 145] among obese men, with a strong inverse relationship also detected among overweight men [high vs low AMH; OR 0.011 (95% CI 0.0004, 0.27); P = 0.007; N 5 193]. An inverse relationship between continuous AMH and diabetes [OR 0.75 (95% CI: 0.59, 0.93); P = 0.011; N 5 193] was also detected among overweight men. Conclusions: AMH was associated with specific cardiometabolic risk factors, including WC, diabetes status, and insulin resistance, in overweight and obese US men.

Original languageEnglish (US)
Pages (from-to)921-936
Number of pages16
JournalJournal of the Endocrine Society
Volume3
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Anti-Müllerian hormone
  • Diabetes
  • Inflammation
  • Insulin resistance
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Anti-Müllerian hormone levels and cardiometabolic disturbances by weight status among men in the 1999 to 2004 national health and nutrition examination survey'. Together they form a unique fingerprint.

  • Cite this