Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts

Seungyoun Jung; Naomi Allen; Alan A. Arslan; Laura Baglietto; Aurelio Barricarte; Louise A. Brinton; Brian L. Egleston; Roni T. Falk; Renée T. Fortner; Kathy J. Helzlsouer; Yutang Gao; Annika Idahl; Rudolph Kaaks; Vittorio Krogh; Melissa A. Merritt; Eva Lundin; N. Charlotte Onland-Moret; Sabina Rinaldi; Helena Schock; Xiao Ou Shu; Patrick M. Sluss; Paul N. Staats; Carlotta Sacerdote; Ruth C. Travis; Anne Tjønneland; Antonia Trichopoulou; Shelley S. Tworoger; Kala Visvanathan; Elisabete Weiderpass; Anne Zeleniuch-Jacquotte; Joanne F. Dorgan

doi:10.1002/ijc.31058

Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts

Seungyoun Jung, Naomi Allen, Alan A. Arslan, Laura Baglietto, Aurelio Barricarte, Louise A. Brinton, Brian L. Egleston, Roni T. Falk, Renée T. Fortner, Kathy J. Helzlsouer, Yutang Gao, Annika Idahl, Rudolph Kaaks, Vittorio Krogh, Melissa A. Merritt, Eva Lundin, N. Charlotte Onland-Moret, Sabina Rinaldi, Helena Schock, Xiao Ou ShuPatrick M. Sluss, Paul N. Staats, Carlotta Sacerdote, Ruth C. Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley S. Tworoger, Kala Visvanathan, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Joanne F. Dorgan

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable-adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (P_trend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all P_{heterogeneity}: ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all P_{heterogeneity}: ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.

Original language	English (US)
Pages (from-to)	262-270
Number of pages	9
Journal	International Journal of Cancer
Volume	142
Issue number	2
DOIs	https://doi.org/10.1002/ijc.31058
State	Published - Jan 15 2018

Keywords

anti-Müllerian hormone
epidemiology
ovarian cancer
ovarian function

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/ijc.31058

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Jung, S., Allen, N., Arslan, A. A., Baglietto, L., Barricarte, A., Brinton, L. A., Egleston, B. L., Falk, R. T., Fortner, R. T., Helzlsouer, K. J., Gao, Y., Idahl, A., Kaaks, R., Krogh, V., Merritt, M. A., Lundin, E., Onland-Moret, N. C., Rinaldi, S., Schock, H., ... Dorgan, J. F. (2018). Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts. International Journal of Cancer, 142(2), 262-270. https://doi.org/10.1002/ijc.31058

Jung, S, Allen, N, Arslan, AA, Baglietto, L, Barricarte, A, Brinton, LA, Egleston, BL, Falk, RT, Fortner, RT, Helzlsouer, KJ, Gao, Y, Idahl, A, Kaaks, R, Krogh, V, Merritt, MA, Lundin, E, Onland-Moret, NC, Rinaldi, S, Schock, H, Shu, XO, Sluss, PM, Staats, PN, Sacerdote, C, Travis, RC, Tjønneland, A, Trichopoulou, A, Tworoger, SS, Visvanathan, K, Weiderpass, E, Zeleniuch-Jacquotte, A & Dorgan, JF 2018, 'Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts', International Journal of Cancer, vol. 142, no. 2, pp. 262-270. https://doi.org/10.1002/ijc.31058

@article{32ac48569c114be4974c2b26ef15ceae,

title = "Anti-M{\"u}llerian hormone and risk of ovarian cancer in nine cohorts",

abstract = "Animal and experimental data suggest that anti-M{\"u}llerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable-adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (Ptrend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all Pheterogeneity: ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all Pheterogeneity: ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.",

keywords = "anti-M{\"u}llerian hormone, epidemiology, ovarian cancer, ovarian function",

author = "Seungyoun Jung and Naomi Allen and Arslan, {Alan A.} and Laura Baglietto and Aurelio Barricarte and Brinton, {Louise A.} and Egleston, {Brian L.} and Falk, {Roni T.} and Fortner, {Ren{\'e}e T.} and Helzlsouer, {Kathy J.} and Yutang Gao and Annika Idahl and Rudolph Kaaks and Vittorio Krogh and Merritt, {Melissa A.} and Eva Lundin and Onland-Moret, {N. Charlotte} and Sabina Rinaldi and Helena Schock and Shu, {Xiao Ou} and Sluss, {Patrick M.} and Staats, {Paul N.} and Carlotta Sacerdote and Travis, {Ruth C.} and Anne Tj{\o}nneland and Antonia Trichopoulou and Tworoger, {Shelley S.} and Kala Visvanathan and Elisabete Weiderpass and Anne Zeleniuch-Jacquotte and Dorgan, {Joanne F.}",

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doi = "10.1002/ijc.31058",

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AU - Jung, Seungyoun

AU - Allen, Naomi

AU - Arslan, Alan A.

AU - Baglietto, Laura

AU - Barricarte, Aurelio

AU - Brinton, Louise A.

AU - Egleston, Brian L.

AU - Falk, Roni T.

AU - Fortner, Renée T.

AU - Helzlsouer, Kathy J.

AU - Gao, Yutang

AU - Idahl, Annika

AU - Kaaks, Rudolph

AU - Krogh, Vittorio

AU - Merritt, Melissa A.

AU - Lundin, Eva

AU - Onland-Moret, N. Charlotte

AU - Rinaldi, Sabina

AU - Schock, Helena

AU - Shu, Xiao Ou

AU - Sluss, Patrick M.

AU - Staats, Paul N.

AU - Sacerdote, Carlotta

AU - Travis, Ruth C.

AU - Tjønneland, Anne

AU - Trichopoulou, Antonia

AU - Tworoger, Shelley S.

AU - Visvanathan, Kala

AU - Weiderpass, Elisabete

AU - Zeleniuch-Jacquotte, Anne

AU - Dorgan, Joanne F.

PY - 2018/1/15

Y1 - 2018/1/15

N2 - Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable-adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (Ptrend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all Pheterogeneity: ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all Pheterogeneity: ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.

AB - Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable-adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (Ptrend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all Pheterogeneity: ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all Pheterogeneity: ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.

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KW - ovarian function

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ER -

Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts

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