Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography

Florian Wegner; Florian Wilke; Peter Raab; Said B. Tayeb; Anna Lena Boeck; Cathleen Haense; Corinna Trebst; Elke Voss; Christoph Schrader; Frank Logemann; Jörg Ahrens; Andreas Leffler; Rea Rodriguez-Raecke; Reinhard Dengler; Lilli Geworski; Frank M. Bengel; Georg Berding; Martin Stangel; Elham Nabavi

doi:10.1186/1471-2377-14-136

Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography

Florian Wegner, Florian Wilke, Peter Raab, Said B. Tayeb, Anna Lena Boeck, Cathleen Haense, Corinna Trebst, Elke Voss, Christoph Schrader, Frank Logemann, Jörg Ahrens, Andreas Leffler, Rea Rodriguez-Raecke, Reinhard Dengler, Lilli Geworski, Frank M. Bengel, Georg Berding, Martin Stangel, Elham Nabavi

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis.Methods: The brain ¹⁸F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls.Results: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism.Conclusions: This retrospective ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis.

Original language	English (US)
Article number	136
Journal	BMC neurology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/1471-2377-14-136
State	Published - Jun 20 2014
Externally published	Yes

Keywords

18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET)
Anti- N-methyl-D-aspartate (NMDA) receptor antibody
Anti- leucine rich glioma inactivated 1 protein (LGI1)
Autoimmune limbic encephalitis
Brain glucose metabolism
Paraneoplastic syndrome

ASJC Scopus subject areas

Clinical Neurology

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Wegner, F., Wilke, F., Raab, P., Tayeb, S. B., Boeck, A. L., Haense, C., Trebst, C., Voss, E., Schrader, C., Logemann, F., Ahrens, J., Leffler, A., Rodriguez-Raecke, R., Dengler, R., Geworski, L., Bengel, F. M., Berding, G., Stangel, M., & Nabavi, E. (2014). Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography. BMC neurology, 14(1), Article 136. https://doi.org/10.1186/1471-2377-14-136

Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography. / Wegner, Florian; Wilke, Florian; Raab, Peter et al.
In: BMC neurology, Vol. 14, No. 1, 136, 20.06.2014.

Research output: Contribution to journal › Article › peer-review

Wegner, F, Wilke, F, Raab, P, Tayeb, SB, Boeck, AL, Haense, C, Trebst, C, Voss, E, Schrader, C, Logemann, F, Ahrens, J, Leffler, A, Rodriguez-Raecke, R, Dengler, R, Geworski, L, Bengel, FM, Berding, G, Stangel, M & Nabavi, E 2014, 'Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography', BMC neurology, vol. 14, no. 1, 136. https://doi.org/10.1186/1471-2377-14-136

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title = "Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography",

abstract = "Background: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in 18F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis.Methods: The brain 18F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls.Results: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism.Conclusions: This retrospective 18F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis.",

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author = "Florian Wegner and Florian Wilke and Peter Raab and Tayeb, {Said B.} and Boeck, {Anna Lena} and Cathleen Haense and Corinna Trebst and Elke Voss and Christoph Schrader and Frank Logemann and J{\"o}rg Ahrens and Andreas Leffler and Rea Rodriguez-Raecke and Reinhard Dengler and Lilli Geworski and Bengel, {Frank M.} and Georg Berding and Martin Stangel and Elham Nabavi",

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doi = "10.1186/1471-2377-14-136",

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T1 - Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography

AU - Wegner, Florian

AU - Wilke, Florian

AU - Raab, Peter

AU - Tayeb, Said B.

AU - Boeck, Anna Lena

AU - Haense, Cathleen

AU - Trebst, Corinna

AU - Voss, Elke

AU - Schrader, Christoph

AU - Logemann, Frank

AU - Ahrens, Jörg

AU - Leffler, Andreas

AU - Rodriguez-Raecke, Rea

AU - Dengler, Reinhard

AU - Geworski, Lilli

AU - Bengel, Frank M.

AU - Berding, Georg

AU - Stangel, Martin

AU - Nabavi, Elham

PY - 2014/6/20

Y1 - 2014/6/20

N2 - Background: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in 18F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis.Methods: The brain 18F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls.Results: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism.Conclusions: This retrospective 18F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis.

AB - Background: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in 18F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis.Methods: The brain 18F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls.Results: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism.Conclusions: This retrospective 18F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis.

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KW - Anti- leucine rich glioma inactivated 1 protein (LGI1)

KW - Autoimmune limbic encephalitis

KW - Brain glucose metabolism

KW - Paraneoplastic syndrome

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