Anti-la antibody diminishes ocular inflammation in experimental autoimmune uveitis

Richard Wetzig, John J. Hooks, Caroline M. Percopo, Robert Nussenblatt, Chi Chao Chan, Barbara Detrick

Research output: Contribution to journalArticle

Abstract

An experimental model of inflammatory eye disease, experimental autoimmmune uveitis (EAU), was established by injecting rats in the footpad with S-antigen in complete Freund's adjuvant. This model system was used to evaluate the role of major histocompatibility complex (MHC) class II antigens (la) in the pathogenesis of this T cell mediated disease. One day prior to S-antigen priming, rats were injected with either anti-la antibodies or with mouse ascites. Clinical and histopathological analysis of eyes from rats treated with anti-la antibody showed less ocular inflammation as well as a delay in onset of EAU when compared to controls (p=0.01). Furthermore, immunocytochemical evaluation demonstrated that tissue obtained from animals receiving anti-la therapy also expressed less la antigen, as well as a diminution in the number of infiltrating macrophages and lymphocytes. These data show that anti-la treatment significantly modifies the course of EAU in the rat. In addition, this study suggests that MHC class II antigen expression may be involved in the initiation and continuation of immune responses that results in ocular inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)809-818
Number of pages10
JournalCurrent Eye Research
Volume7
Issue number8
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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