@article{6a7c44d0e41046c69cdc8fad18b3cdc1,
title = "Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons with Human Immunodeficiency Virus",
abstract = "Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque (P =. 01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = -0.19; P =. 02) and noncalcified coronary plaque (ρ = -0.24; P =. 004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH. Clinical Trials Registration.",
keywords = "HIV, IL-10, Inflammation, atherosclerosis",
author = "Fourman, {Lindsay T.} and Saylor, {Charles F.} and Lediya Cheru and Kathleen Fitch and Sara Looby and Kiana Keller and Robinson, {Jake A.} and Udo Hoffmann and Lu, {Michael T.} and Tricia Burdo and Janet Lo",
note = "Funding Information: Financial support. This work was supported by the National Institutes of Health (grant 1KL2TR002542-01 to L. T. F., RO1HL123351 and K23HL092792 to J. L. and 5T32DK007028-44 to L. C.), Bristol-Myers Squibb, (grant 1 UL1 RR025758-04), the Harvard Clinical and Translational Science Center, and the National Center for Research Resources. Funding Information: Potential conflicts of interest. U. H. received grant support from MedImmune, Kowa, and HeartFlow, unrelated to this work. M. T. L. received consulting fees from PQBypass, research support from NVIDIA, grant support from MedImmune, and research funding from Kowa, unrelated to this work. J. L. has served on a medical affairs advisory board for Gilead Sciences and as a consultant for ViiV Healthcare, unrelated to this work. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",
year = "2020",
month = feb,
day = "3",
doi = "10.1093/infdis/jiz254",
language = "English (US)",
volume = "221",
pages = "510--515",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}