Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons with Human Immunodeficiency Virus

Lindsay T. Fourman, Charles F. Saylor, Lediya Cheru, Kathleen Fitch, Sara Looby, Kiana Keller, Jake A. Robinson, Udo Hoffmann, Michael T. Lu, Tricia Burdo, Janet Lo

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque (P =. 01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = -0.19; P =. 02) and noncalcified coronary plaque (ρ = -0.24; P =. 004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH. Clinical Trials Registration. NCT00455793

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalJournal of Infectious Diseases
Volume221
Issue number4
DOIs
StatePublished - Feb 3 2020
Externally publishedYes

Keywords

  • HIV
  • IL-10
  • Inflammation
  • atherosclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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