Anti-inflammatory effects of granulocyte colony-stimulating factor

Research output: Contribution to journalReview article

Abstract

The innate, unspecific immune response to bacterial and fungal infection is mediated primarily by neutrophilic granulocytes. Granulocyte colony-stimulating factor (G-CSF), an endogenous hematopoietic growth factor for neutrophils produced at the site of infection, is an integral part of this natural host defense. However, neutrophilic granulocytes also play a major role in the inflammatory response, resulting in tissue damage. Therefore, the indications for colony-stimulating factors in combating infectious diseases seemed to be limited for fear of their proinflammatory activity. In contrast to these concerns, G-CSF has proven itself to be an anti-inflammatory immunomodulator. Animal, volunteer, and patient studies have all shown that G-CSF reduces inflammatory activity by inhibiting the production or activity of the main inflammatory mediators interleukin-1, tumor necrosis factor-α, and interferon gamma. In conclusion, the body's G-CSF-regulated emergency recruitment of neutrophils is combined with a simultaneous limitation of the harmful inflammatory reaction. This unique pharmacologic combination of improving anti-infectious defense and inhibiting inflammation, opens up a range of new indications for G-CSF in the area of nonneutropenic infections.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalCurrent opinion in hematology
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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