Anti-inflammatory effect of deflazacort

C. Stellato, V. Casolaro, A. Renda, A. Genovese, Gianni Marone

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the effects of deflazacort (DFZ), a methyloxazoline derivative of prednisolone (PRED), PRED and dexamethasone (DEX) on the IgE- mediated release of preformed (histamine) and de novo synthesized (leukotriene C4 (LTC4)) proinflammatory mediators from human peripheral blood basophils. Eighteen-hour incubation of basophils with pharmacological concentrations of DFZ (10-8to 3 × 10-6 M) concentration dependently inhibited (9-50%) the IgE-dependent release of histamine and LTC4 from basophils. DFZ had a similar anti-inflammatory efficacy as DEX (10-9 to 10-6 M) and similar efficacy and potency as PRED (10-8 to 3 × 10-6 M). We also evaluated the effects of DFZ (10-8 to 10-7 M) in combination with cyclosporin A (CsA) on the IgE-mediated histamine and LTC4 release from basophils. Eighteen-hour incubation of basophils with low concentrations of DFZ (10-8 to 10-7 M) produced an additive inhibition of the release of histamine and LTC4 caused by short-term incubation with CsA (30 ng/ml).

Original languageEnglish (US)
Pages (from-to)340-342
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume99
Issue number2-4
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Basophils
  • Corticosteroids
  • Cyclosporin A
  • Deflazacort
  • Histamine
  • Leukotriene C<inf>4</inf>

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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