Anti-inflammatory effect of deflazacort

C. Stellato; V. Casolaro; A. Renda; A. Genovese; Gianni Marone

doi:10.1159/000236279

Anti-inflammatory effect of deflazacort

C. Stellato, V. Casolaro, A. Renda, A. Genovese, Gianni Marone

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We compared the effects of deflazacort (DFZ), a methyloxazoline derivative of prednisolone (PRED), PRED and dexamethasone (DEX) on the IgE- mediated release of preformed (histamine) and de novo synthesized (leukotriene C4 (LTC4)) proinflammatory mediators from human peripheral blood basophils. Eighteen-hour incubation of basophils with pharmacological concentrations of DFZ (10^-8to 3 × 10^-6 M) concentration dependently inhibited (9-50%) the IgE-dependent release of histamine and LTC4 from basophils. DFZ had a similar anti-inflammatory efficacy as DEX (10^-9 to 10^-6 M) and similar efficacy and potency as PRED (10^-8 to 3 × 10^-6 M). We also evaluated the effects of DFZ (10^-8 to 10^-7 M) in combination with cyclosporin A (CsA) on the IgE-mediated histamine and LTC4 release from basophils. Eighteen-hour incubation of basophils with low concentrations of DFZ (10^-8 to 10^-7 M) produced an additive inhibition of the release of histamine and LTC4 caused by short-term incubation with CsA (30 ng/ml).

Original language	English (US)
Pages (from-to)	340-342
Number of pages	3
Journal	International Archives of Allergy and Immunology
Volume	99
Issue number	2-4
DOIs	https://doi.org/10.1159/000236279
State	Published - 1992
Externally published	Yes

Keywords

Basophils
Corticosteroids
Cyclosporin A
Deflazacort
Histamine
Leukotriene C<inf>4</inf>

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1159/000236279

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title = "Anti-inflammatory effect of deflazacort",

abstract = "We compared the effects of deflazacort (DFZ), a methyloxazoline derivative of prednisolone (PRED), PRED and dexamethasone (DEX) on the IgE- mediated release of preformed (histamine) and de novo synthesized (leukotriene C4 (LTC4)) proinflammatory mediators from human peripheral blood basophils. Eighteen-hour incubation of basophils with pharmacological concentrations of DFZ (10-8to 3 × 10-6 M) concentration dependently inhibited (9-50%) the IgE-dependent release of histamine and LTC4 from basophils. DFZ had a similar anti-inflammatory efficacy as DEX (10-9 to 10-6 M) and similar efficacy and potency as PRED (10-8 to 3 × 10-6 M). We also evaluated the effects of DFZ (10-8 to 10-7 M) in combination with cyclosporin A (CsA) on the IgE-mediated histamine and LTC4 release from basophils. Eighteen-hour incubation of basophils with low concentrations of DFZ (10-8 to 10-7 M) produced an additive inhibition of the release of histamine and LTC4 caused by short-term incubation with CsA (30 ng/ml).",

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author = "C. Stellato and V. Casolaro and A. Renda and A. Genovese and Gianni Marone",

year = "1992",

doi = "10.1159/000236279",

language = "English (US)",

volume = "99",

pages = "340--342",

journal = "International Archives of Allergy and Immunology",

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TY - JOUR

T1 - Anti-inflammatory effect of deflazacort

AU - Stellato, C.

AU - Casolaro, V.

AU - Renda, A.

AU - Genovese, A.

AU - Marone, Gianni

PY - 1992

Y1 - 1992

N2 - We compared the effects of deflazacort (DFZ), a methyloxazoline derivative of prednisolone (PRED), PRED and dexamethasone (DEX) on the IgE- mediated release of preformed (histamine) and de novo synthesized (leukotriene C4 (LTC4)) proinflammatory mediators from human peripheral blood basophils. Eighteen-hour incubation of basophils with pharmacological concentrations of DFZ (10-8to 3 × 10-6 M) concentration dependently inhibited (9-50%) the IgE-dependent release of histamine and LTC4 from basophils. DFZ had a similar anti-inflammatory efficacy as DEX (10-9 to 10-6 M) and similar efficacy and potency as PRED (10-8 to 3 × 10-6 M). We also evaluated the effects of DFZ (10-8 to 10-7 M) in combination with cyclosporin A (CsA) on the IgE-mediated histamine and LTC4 release from basophils. Eighteen-hour incubation of basophils with low concentrations of DFZ (10-8 to 10-7 M) produced an additive inhibition of the release of histamine and LTC4 caused by short-term incubation with CsA (30 ng/ml).

AB - We compared the effects of deflazacort (DFZ), a methyloxazoline derivative of prednisolone (PRED), PRED and dexamethasone (DEX) on the IgE- mediated release of preformed (histamine) and de novo synthesized (leukotriene C4 (LTC4)) proinflammatory mediators from human peripheral blood basophils. Eighteen-hour incubation of basophils with pharmacological concentrations of DFZ (10-8to 3 × 10-6 M) concentration dependently inhibited (9-50%) the IgE-dependent release of histamine and LTC4 from basophils. DFZ had a similar anti-inflammatory efficacy as DEX (10-9 to 10-6 M) and similar efficacy and potency as PRED (10-8 to 3 × 10-6 M). We also evaluated the effects of DFZ (10-8 to 10-7 M) in combination with cyclosporin A (CsA) on the IgE-mediated histamine and LTC4 release from basophils. Eighteen-hour incubation of basophils with low concentrations of DFZ (10-8 to 10-7 M) produced an additive inhibition of the release of histamine and LTC4 caused by short-term incubation with CsA (30 ng/ml).

KW - Basophils

KW - Corticosteroids

KW - Cyclosporin A

KW - Deflazacort

KW - Histamine

KW - Leukotriene C<inf>4</inf>

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JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

IS - 2-4

ER -

Anti-inflammatory effect of deflazacort

Abstract

Keywords

ASJC Scopus subject areas

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