Anti-inflammatory aspects of filgrastim and impact on IL-2 release

Research output: Contribution to journalReview article

Abstract

G-CSF has immunomodulatory effects of neutrophilic granulocytes and monocytes/macrophages. Two studies were done: one in normal volunteers and the other in HIV-infected patients plus their respective control donors to evaluate the effect of Filgrastim on cytokine responses. Filgrastim treatment of volunteers resulted in anti-inflammatory cytokine response, when blood was stimulated ex vivo with the endotoxin lipopolysaccharide (LPS). Similarly, in the presence of Filgrastim in vitro, the LPS-inducible release of proinflammatory cytokines was attenuated. Blood from HIV-infected patients at advanced stages of disease showed reduced interleukin (IL)-2 formation in response to staphylococcal exotoxin B (SEB), which was restored in the presence of Filgrastim.

Original languageEnglish (US)
Pages (from-to)S21-S22
JournalJournal of Hematotherapy and Stem Cell Research
Volume8
Issue numberSUPPL. 1
StatePublished - Dec 17 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Hematology

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