Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte, Yannick Estevez, Robert H. Gilman, Walter H. Lewis, Rosario Rojas, Michel Sauvain, Abraham J. Vaisberg, Gerald B. Hammond

Research output: Contribution to journalArticlepeer-review

Abstract

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

Original languageEnglish (US)
Pages (from-to)407-410
Number of pages4
JournalPlanta Medica
Volume74
Issue number4
DOIs
StatePublished - Mar 1 2008

Keywords

  • Anti-infective
  • Antileishmania
  • Asclepiadaceae
  • Blepharodon nitidum
  • Cytotoxic
  • Hydroperoxycycloartanes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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