Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte; Yannick Estevez; Robert H. Gilman; Walter H. Lewis; Rosario Rojas; Michel Sauvain; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1055/s-2008-1034330

Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte, Yannick Estevez, Robert H. Gilman, Walter H. Lewis, Rosario Rojas, Michel Sauvain, Abraham J. Vaisberg, Gerald B. Hammond

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

Original language	English (US)
Pages (from-to)	407-410
Number of pages	4
Journal	Planta Medica
Volume	74
Issue number	4
DOIs	https://doi.org/10.1055/s-2008-1034330
State	Published - Mar 2008

Keywords

Anti-infective
Antileishmania
Asclepiadaceae
Blepharodon nitidum
Cytotoxic
Hydroperoxycycloartanes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Anti-infective and cytotoxic compounds present in Blepharodon nitidum",

abstract = "A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.",

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T1 - Anti-infective and cytotoxic compounds present in Blepharodon nitidum

AU - Aponte, José C.

AU - Estevez, Yannick

AU - Gilman, Robert H.

AU - Lewis, Walter H.

AU - Rojas, Rosario

AU - Sauvain, Michel

AU - Vaisberg, Abraham J.

AU - Hammond, Gerald B.

PY - 2008/3

Y1 - 2008/3

N2 - A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

AB - A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

KW - Anti-infective

KW - Antileishmania

KW - Asclepiadaceae

KW - Blepharodon nitidum

KW - Cytotoxic

KW - Hydroperoxycycloartanes

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Anti-infective and cytotoxic compounds present in Blepharodon nitidum

Abstract

Keywords

ASJC Scopus subject areas

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