Anti-idiotypic antibodies: Biological function and structural studies

Y. Pan, S. C. Yuhasz, Mario L Amzel

Research output: Contribution to journalArticle

Abstract

Under a variety of circumstances antibodies can be elicited against the variable region of other antibody molecules (anti-idotypic antibodies, anti- ids). Some of the antibodies are directed against the binding sites of the eliciting antibodies. Of particular interest are the antibodies that recognize epitopes of the original antibody that are in contact with antigen. Antibodies of this kind have been produced and used in a variety of situations including attempts at using them as therapeutic agents. In recent years structural data at the atomic level have emerged for anti-idiotypic antibodies from X-ray diffraction studies. These studies provided structural basis for molecular mimicry of anti-ids. For a large globular antigen (lysozyme), where epitope is noncontinuguous, molecular mimicry is not present at the atomic level. In this case, idiotopes are largely composed of CDR residues, but framework residues are also used. For an epitope that is sequence-specific (anti-FIPV system), molecular mimicry appears to be present as evidenced by the sequence homology between the CDR loops of the anti-id and the epitope of the original antigen. In the case of a small hormone antigen (angiotensin II), an internal image of the eliciting antigen appears to be represented in a single CDR loop of the antiiodiotypic antibody.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalFASEB Journal
Volume9
Issue number1
StatePublished - 1995

Fingerprint

Anti-Idiotypic Antibodies
antibodies
Molecular Mimicry
Antibodies
Epitopes
molecular mimicry
Antigens
epitopes
antigens
Feline Coronavirus
Antibody Binding Sites
Muramidase
Sequence Homology
X-Ray Diffraction
Angiotensin II
angiotensin II
sequence homology
lysozyme
X-ray diffraction
Hormones

Keywords

  • anti-idotype
  • epitopes
  • mimicry

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Anti-idiotypic antibodies : Biological function and structural studies. / Pan, Y.; Yuhasz, S. C.; Amzel, Mario L.

In: FASEB Journal, Vol. 9, No. 1, 1995, p. 43-49.

Research output: Contribution to journalArticle

Pan, Y. ; Yuhasz, S. C. ; Amzel, Mario L. / Anti-idiotypic antibodies : Biological function and structural studies. In: FASEB Journal. 1995 ; Vol. 9, No. 1. pp. 43-49.
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