TY - JOUR
T1 - Anti-HIV microRNA expression in a novel Indian cohort
AU - Dey, Rakesh
AU - Soni, Kartik
AU - Saravanan, Shanmugam
AU - Balakrishnan, Pachamuthu
AU - Kumar, Vikram
AU - Boobalan, Jayaseelan
AU - Solomon, Sunil Suhas
AU - Scaria, Vinod
AU - Solomon, Suniti
AU - Brahmachari, Samir K.
AU - Pillai, Beena
PY - 2016/6/20
Y1 - 2016/6/20
N2 - HIV-1 replication inside host cells is known to be regulated by various host factors. Host miRNAs, by virtue of its normal functioning, also regulate HIV-1 RNA expression by either directly targeting virus mRNAs or indirectly by regulating host proteins that HIV-1 uses for own replication. Therefore, it is highly possible that with differential miRNA expression, rate of disease progression will vary in HIV-1 infected individuals. In this study we have compared expression of a panel of 13 reported anti-HIV miRNAs in human PBMCs from long term non progressors (LTNPs), regular progressors and rapid progressors. We found that LTNPs have substantial lower expression of miR-382-5p that positively correlates with viral loads. Combinatorial regulation is highly probable in dictating differential disease progression as average expression of miR-382-5p and miR-155-5p can substantially distinguish LTNP individuals from regular progressors.
AB - HIV-1 replication inside host cells is known to be regulated by various host factors. Host miRNAs, by virtue of its normal functioning, also regulate HIV-1 RNA expression by either directly targeting virus mRNAs or indirectly by regulating host proteins that HIV-1 uses for own replication. Therefore, it is highly possible that with differential miRNA expression, rate of disease progression will vary in HIV-1 infected individuals. In this study we have compared expression of a panel of 13 reported anti-HIV miRNAs in human PBMCs from long term non progressors (LTNPs), regular progressors and rapid progressors. We found that LTNPs have substantial lower expression of miR-382-5p that positively correlates with viral loads. Combinatorial regulation is highly probable in dictating differential disease progression as average expression of miR-382-5p and miR-155-5p can substantially distinguish LTNP individuals from regular progressors.
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U2 - 10.1038/srep28279
DO - 10.1038/srep28279
M3 - Article
C2 - 27320691
AN - SCOPUS:84975488104
SN - 2045-2322
VL - 6
JO - Scientific reports
JF - Scientific reports
M1 - 28279
ER -