Anti gliadin antibodies (AGA IgG) related to peripheral inflammation in schizophrenia

Deanna L. Kelly, Haley K. Demyanovich, William W Eaton, Nicola Cascella, Jessica Jackson, Alessio Fasano, William T. Carpenter

Research output: Contribution to journalArticle

Abstract

Altered immune function and inflammation are seen in schizophrenia, however, peripheral inflammatory markers are not consistently elevated in all people, suggesting inflammation may be present only in a subgroup. We measured TNF-α and IL-Iβ in 100 people with schizophrenia or schizoaffective disorder and correlated these with antibodies to gliadin, a protein found in wheat, barley and rye that has been found to be elevated in some people with schizophrenia. We hypothesized that higher peripheral antigliadin antibodies (AGA IgG) would be associated with higher peripheral inflammation as measured by TNF-α and IL-1β. Mean log transformed values of TNF-α, (p = .029) and IL-1β (p = .016) were over twofold higher in people with schizophrenia who had high levels of AGA IgG (≥7 U) compared to those who did not have positivity to AGA IgG. We found a significant positive correlation between AGA IgG and the log transformed TNF-α (r = 0.42, p. <. .0001) as well as IL-Iβ (r = 0.51, p. <. .0001). The relationship was independent of cigarette smoking, body mass index and antipsychotic medications. People with schizophrenia having higher levels of AGA IgG show higher levels of peripheral inflammation and may define a subgroup with distinct pathophysiology and potentially novel treatment targets.

Original languageEnglish (US)
JournalBrain, Behavior, and Immunity
DOIs
Publication statusAccepted/In press - Jan 1 2017

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Keywords

  • Antibodies
  • Gliadin
  • Inflammation
  • Schizophrenia
  • TNFα

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Kelly, D. L., Demyanovich, H. K., Eaton, W. W., Cascella, N., Jackson, J., Fasano, A., & Carpenter, W. T. (Accepted/In press). Anti gliadin antibodies (AGA IgG) related to peripheral inflammation in schizophrenia. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2017.10.020