Anti-Ge3 causes late-onset hemolytic disease of the newborn: The fourth case in three Hispanic families

Lisa Lee Pate, Jessica C. Myers, Jonathan P. Palma, Maurene Viele, Susan A. Galel, Zenaida Ferrer, Christopher Gonzalez, William E. Benitz, George Garratty, Magali J. Fontaine

Research output: Contribution to journalArticle

Abstract

Background The Gerbich (Ge) blood group system consists of 11 antigens carried on red blood cell (RBC) membrane glycophorins C and D; of these, Ge:3 antigen is of high prevalence, and the anti-Ge3 is found to be clinically significant. Case Report A 34-week neonate born to a Hispanic mother with anti-Ge3 developed late-onset hemolysis with hyperbilirubinemia and was successfully treated with transfusions from her mother. Relevant clinical findings and laboratory results for this case are summarized and compared to three other previously reported cases; all babies were born from a mother of Hispanic ethnicity. Conclusion Hemolytic disease of the fetus and new born associated with anti-Ge3 is rare but should be considered when working up a broadly reactive RBC antibody screen in women of Hispanic ethnicity. Early identification of pregnant women with anti-Ge3 is recommended for prenatal transfusion planning and close monitoring of the newborn infant for evidence of late-onset anemia.

Original languageEnglish (US)
Pages (from-to)2152-2157
Number of pages6
JournalTransfusion
Volume53
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

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Fetal Erythroblastosis
Hispanic Americans
Mothers
Erythrocytes
Newborn Infant
Glycophorin
Antigens
Hyperbilirubinemia
Blood Group Antigens
Hemolysis
Anemia
Pregnant Women
Fetus
Cell Membrane
Antibodies
Late Onset Disorders

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Pate, L. L., Myers, J. C., Palma, J. P., Viele, M., Galel, S. A., Ferrer, Z., ... Fontaine, M. J. (2013). Anti-Ge3 causes late-onset hemolytic disease of the newborn: The fourth case in three Hispanic families. Transfusion, 53(10), 2152-2157. https://doi.org/10.1111/trf.12027

Anti-Ge3 causes late-onset hemolytic disease of the newborn : The fourth case in three Hispanic families. / Pate, Lisa Lee; Myers, Jessica C.; Palma, Jonathan P.; Viele, Maurene; Galel, Susan A.; Ferrer, Zenaida; Gonzalez, Christopher; Benitz, William E.; Garratty, George; Fontaine, Magali J.

In: Transfusion, Vol. 53, No. 10, 10.2013, p. 2152-2157.

Research output: Contribution to journalArticle

Pate, LL, Myers, JC, Palma, JP, Viele, M, Galel, SA, Ferrer, Z, Gonzalez, C, Benitz, WE, Garratty, G & Fontaine, MJ 2013, 'Anti-Ge3 causes late-onset hemolytic disease of the newborn: The fourth case in three Hispanic families', Transfusion, vol. 53, no. 10, pp. 2152-2157. https://doi.org/10.1111/trf.12027
Pate, Lisa Lee ; Myers, Jessica C. ; Palma, Jonathan P. ; Viele, Maurene ; Galel, Susan A. ; Ferrer, Zenaida ; Gonzalez, Christopher ; Benitz, William E. ; Garratty, George ; Fontaine, Magali J. / Anti-Ge3 causes late-onset hemolytic disease of the newborn : The fourth case in three Hispanic families. In: Transfusion. 2013 ; Vol. 53, No. 10. pp. 2152-2157.
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AU - Galel, Susan A.

AU - Ferrer, Zenaida

AU - Gonzalez, Christopher

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