Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Dong Gun Lee, Yoonkyung Park, Mi Ran Kim, Hyun Jun Jung, Young Bae Seu, Kyung Soo Hahm, Eun Rhan Woo

Research output: Contribution to journalArticlepeer-review

Abstract

Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

Original languageEnglish (US)
Pages (from-to)1125-1130
Number of pages6
JournalBiotechnology Letters
Volume26
Issue number14
DOIs
StatePublished - Jul 2004
Externally publishedYes

Keywords

  • Lycium chinense
  • Solanaceae
  • anti-fungal activity
  • dihydro-N-caffeoyltyramine
  • trans-N-caffeoyltyramine
  • trans-N-feruloyloctopamine

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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