Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease

Feng Jung Yang, Kai Hsiang Shu, Hung Yuan Chen, I. Yu Chen, Fang Yun Lay, Yi Fang Chuang, Chien Sheng Wu, Wan Chuan Tsai, Yu Sen Peng, Shih Ping Hsu, Chih Kang Chiang, George Cho-Ching Wang, Yen Ling Chiu

Research output: Contribution to journalArticle

Abstract

Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.

Original languageEnglish (US)
Article number15
JournalImmunity and Ageing
Volume15
Issue number1
DOIs
StatePublished - Jul 2 2018

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Cytomegalovirus
Chronic Kidney Failure
Coronary Artery Disease
Cell Differentiation
T-Lymphocytes
Antibodies
Immunoglobulin G
Cytomegalovirus Infections
Logistic Models
anti-IgG
Premature Mortality
Humoral Immunity
C-Reactive Protein
Renal Dialysis
Immunity
Atherosclerosis
Hemoglobins
Kidney
Health
Population

Keywords

  • Cardiovascular disease
  • Cytomegalovirus
  • End-stage renal disease
  • Immunology
  • Immunosenescence

ASJC Scopus subject areas

  • Immunology
  • Aging

Cite this

Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease. / Yang, Feng Jung; Shu, Kai Hsiang; Chen, Hung Yuan; Chen, I. Yu; Lay, Fang Yun; Chuang, Yi Fang; Wu, Chien Sheng; Tsai, Wan Chuan; Peng, Yu Sen; Hsu, Shih Ping; Chiang, Chih Kang; Wang, George Cho-Ching; Chiu, Yen Ling.

In: Immunity and Ageing, Vol. 15, No. 1, 15, 02.07.2018.

Research output: Contribution to journalArticle

Yang, Feng Jung ; Shu, Kai Hsiang ; Chen, Hung Yuan ; Chen, I. Yu ; Lay, Fang Yun ; Chuang, Yi Fang ; Wu, Chien Sheng ; Tsai, Wan Chuan ; Peng, Yu Sen ; Hsu, Shih Ping ; Chiang, Chih Kang ; Wang, George Cho-Ching ; Chiu, Yen Ling. / Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease. In: Immunity and Ageing. 2018 ; Vol. 15, No. 1.
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abstract = "Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95{\%} CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.",
keywords = "Cardiovascular disease, Cytomegalovirus, End-stage renal disease, Immunology, Immunosenescence",
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T1 - Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease

AU - Yang, Feng Jung

AU - Shu, Kai Hsiang

AU - Chen, Hung Yuan

AU - Chen, I. Yu

AU - Lay, Fang Yun

AU - Chuang, Yi Fang

AU - Wu, Chien Sheng

AU - Tsai, Wan Chuan

AU - Peng, Yu Sen

AU - Hsu, Shih Ping

AU - Chiang, Chih Kang

AU - Wang, George Cho-Ching

AU - Chiu, Yen Ling

PY - 2018/7/2

Y1 - 2018/7/2

N2 - Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.

AB - Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.

KW - Cardiovascular disease

KW - Cytomegalovirus

KW - End-stage renal disease

KW - Immunology

KW - Immunosenescence

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JO - Immunity and Ageing

JF - Immunity and Ageing

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