Anti-C1q antibodies in systemic lupus erythematosus

A. M. Orbai; L. Truedsson; G. Sturfelt; O. Nived; H. Fang; G. S. Alarcón; C. Gordon; J. T. Merrill; P. R. Fortin; I. N. Bruce; D. A. Isenberg; D. J. Wallace; R. Ramsey-Goldman; S. C. Bae; J. G. Hanly; J. Sanchez-Guerrero; A. E. Clarke; C. B. Aranow; S. Manzi; M. B. Urowitz; D. D. Gladman; K. C. Kalunian; M. I. Costner; V. P. Werth; A. Zoma; S. Bernatsky; G. Ruiz-Irastorza; M. A. Khamashta; S. Jacobsen; J. P. Buyon; P. Maddison; M. A. Dooley; R. F. Van Vollenhoven; E. Ginzler; T. Stoll; C. Peschken; J. L. Jorizzo; J. P. Callen; S. S. Lim; B. J. Fessler; M. Inanc; D. L. Kamen; A. Rahman; K. Steinsson; A. G. Franks; L. Sigler; S. Hameed; N. Pham; R. Brey; M. H. Weisman; G. McGwin; L. S. Magder; M. Petri

doi:10.1177/0961203314547791

Anti-C1q antibodies in systemic lupus erythematosus

A. M. Orbai, L. Truedsson, G. Sturfelt, O. Nived, H. Fang, G. S. Alarcón, C. Gordon, J. T. Merrill, P. R. Fortin, I. N. Bruce, D. A. Isenberg, D. J. Wallace, R. Ramsey-Goldman, S. C. Bae, J. G. Hanly, J. Sanchez-Guerrero, A. E. Clarke, C. B. Aranow, S. Manzi, M. B. UrowitzD. D. Gladman, K. C. Kalunian, M. I. Costner, V. P. Werth, A. Zoma, S. Bernatsky, G. Ruiz-Irastorza, M. A. Khamashta, S. Jacobsen, J. P. Buyon, P. Maddison, M. A. Dooley, R. F. Van Vollenhoven, E. Ginzler, T. Stoll, C. Peschken, J. L. Jorizzo, J. P. Callen, S. S. Lim, B. J. Fessler, M. Inanc, D. L. Kamen, A. Rahman, K. Steinsson, A. G. Franks, L. Sigler, S. Hameed, N. Pham, R. Brey, M. H. Weisman, G. McGwin, L. S. Magder, M. Petri

School of Medicine

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Objective: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.

Methods: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.

Results: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p<0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p<0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p<0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p<0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p<0.01).

Conclusions: Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis. Lupus (2015) 24, 42-49.

Original language	English (US)
Pages (from-to)	42-49
Number of pages	8
Journal	Lupus
Volume	24
Issue number	1
DOIs	https://doi.org/10.1177/0961203314547791
State	Published - Jan 16 2015

Keywords

Anti-dsDNA antibodies
renal lupus
systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology

Access to Document

10.1177/0961203314547791

Cite this

Orbai, A. M., Truedsson, L., Sturfelt, G., Nived, O., Fang, H., Alarcón, G. S., Gordon, C., Merrill, J. T., Fortin, P. R., Bruce, I. N., Isenberg, D. A., Wallace, D. J., Ramsey-Goldman, R., Bae, S. C., Hanly, J. G., Sanchez-Guerrero, J., Clarke, A. E., Aranow, C. B., Manzi, S., ... Petri, M. (2015). Anti-C1q antibodies in systemic lupus erythematosus. Lupus, 24(1), 42-49. https://doi.org/10.1177/0961203314547791

Orbai, AM, Truedsson, L, Sturfelt, G, Nived, O, Fang, H, Alarcón, GS, Gordon, C, Merrill, JT, Fortin, PR, Bruce, IN, Isenberg, DA, Wallace, DJ, Ramsey-Goldman, R, Bae, SC, Hanly, JG, Sanchez-Guerrero, J, Clarke, AE, Aranow, CB, Manzi, S, Urowitz, MB, Gladman, DD, Kalunian, KC, Costner, MI, Werth, VP, Zoma, A, Bernatsky, S, Ruiz-Irastorza, G, Khamashta, MA, Jacobsen, S, Buyon, JP, Maddison, P, Dooley, MA, Van Vollenhoven, RF, Ginzler, E, Stoll, T, Peschken, C, Jorizzo, JL, Callen, JP, Lim, SS, Fessler, BJ, Inanc, M, Kamen, DL, Rahman, A, Steinsson, K, Franks, AG, Sigler, L, Hameed, S, Pham, N, Brey, R, Weisman, MH, McGwin, G, Magder, LS & Petri, M 2015, 'Anti-C1q antibodies in systemic lupus erythematosus', Lupus, vol. 24, no. 1, pp. 42-49. https://doi.org/10.1177/0961203314547791

@article{0e2188bc7b0c4cfaaaf275c3f8aaa349,

title = "Anti-C1q antibodies in systemic lupus erythematosus",

abstract = "Objective: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.Methods: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.Results: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p<0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p<0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p<0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p<0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p<0.01).Conclusions: Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis. Lupus (2015) 24, 42-49.",

keywords = "Anti-dsDNA antibodies, renal lupus, systemic lupus erythematosus",

author = "Orbai, {A. M.} and L. Truedsson and G. Sturfelt and O. Nived and H. Fang and Alarc{\'o}n, {G. S.} and C. Gordon and Merrill, {J. T.} and Fortin, {P. R.} and Bruce, {I. N.} and Isenberg, {D. A.} and Wallace, {D. J.} and R. Ramsey-Goldman and Bae, {S. C.} and Hanly, {J. G.} and J. Sanchez-Guerrero and Clarke, {A. E.} and Aranow, {C. B.} and S. Manzi and Urowitz, {M. B.} and Gladman, {D. D.} and Kalunian, {K. C.} and Costner, {M. I.} and Werth, {V. P.} and A. Zoma and S. Bernatsky and G. Ruiz-Irastorza and Khamashta, {M. A.} and S. Jacobsen and Buyon, {J. P.} and P. Maddison and Dooley, {M. A.} and {Van Vollenhoven}, {R. F.} and E. Ginzler and T. Stoll and C. Peschken and Jorizzo, {J. L.} and Callen, {J. P.} and Lim, {S. S.} and Fessler, {B. J.} and M. Inanc and Kamen, {D. L.} and A. Rahman and K. Steinsson and Franks, {A. G.} and L. Sigler and S. Hameed and N. Pham and R. Brey and Weisman, {M. H.} and G. McGwin and Magder, {L. S.} and M. Petri",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.",

year = "2015",

month = jan,

day = "16",

doi = "10.1177/0961203314547791",

language = "English (US)",

volume = "24",

pages = "42--49",

journal = "Lupus",

issn = "0961-2033",

publisher = "SAGE Publications Ltd",

number = "1",

}

TY - JOUR

T1 - Anti-C1q antibodies in systemic lupus erythematosus

AU - Orbai, A. M.

AU - Truedsson, L.

AU - Sturfelt, G.

AU - Nived, O.

AU - Fang, H.

AU - Alarcón, G. S.

AU - Gordon, C.

AU - Merrill, J. T.

AU - Fortin, P. R.

AU - Bruce, I. N.

AU - Isenberg, D. A.

AU - Wallace, D. J.

AU - Ramsey-Goldman, R.

AU - Bae, S. C.

AU - Hanly, J. G.

AU - Sanchez-Guerrero, J.

AU - Clarke, A. E.

AU - Aranow, C. B.

AU - Manzi, S.

AU - Urowitz, M. B.

AU - Gladman, D. D.

AU - Kalunian, K. C.

AU - Costner, M. I.

AU - Werth, V. P.

AU - Zoma, A.

AU - Bernatsky, S.

AU - Ruiz-Irastorza, G.

AU - Khamashta, M. A.

AU - Jacobsen, S.

AU - Buyon, J. P.

AU - Maddison, P.

AU - Dooley, M. A.

AU - Van Vollenhoven, R. F.

AU - Ginzler, E.

AU - Stoll, T.

AU - Peschken, C.

AU - Jorizzo, J. L.

AU - Callen, J. P.

AU - Lim, S. S.

AU - Fessler, B. J.

AU - Inanc, M.

AU - Kamen, D. L.

AU - Rahman, A.

AU - Steinsson, K.

AU - Franks, A. G.

AU - Sigler, L.

AU - Hameed, S.

AU - Pham, N.

AU - Brey, R.

AU - Weisman, M. H.

AU - McGwin, G.

AU - Magder, L. S.

AU - Petri, M.

PY - 2015/1/16

Y1 - 2015/1/16

N2 - Objective: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.Methods: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.Results: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p<0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p<0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p<0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p<0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p<0.01).Conclusions: Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis. Lupus (2015) 24, 42-49.

AB - Objective: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.Methods: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.Results: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p<0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p<0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p<0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p<0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p<0.01).Conclusions: Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis. Lupus (2015) 24, 42-49.

KW - Anti-dsDNA antibodies

KW - renal lupus

KW - systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=84918547572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918547572&partnerID=8YFLogxK

U2 - 10.1177/0961203314547791

DO - 10.1177/0961203314547791

M3 - Article

C2 - 25124676

AN - SCOPUS:84918547572

SN - 0961-2033

VL - 24

SP - 42

EP - 49

JO - Lupus

JF - Lupus

IS - 1

ER -

Anti-C1q antibodies in systemic lupus erythematosus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this