Anti-atherosclerotic effects of statins: Lessons from prevention trials

Santhi K. Ganesh, Caitlin M. Nass, Roger S. Blumenthal

Research output: Contribution to journalArticlepeer-review

Abstract

Statins are best-known for their lipid-lowering effects and have been shown to significantly impact the natural progression of coronary atherosclerosis. The mechanism through which they exert this effect is thought to be primarily due to their ability to reduce low-density lipoprotein cholesterol levels. However, there is increasing evidence that statins exert a myriad of other beneficial effects on the vascular wall, thus altering the course of atherosclerotic disease. This article will review the prevention trial literature as it pertains to the effects of statin therapy on atherosclerosis.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalEuropean Journal of Preventive Cardiology
Volume10
Issue number3
DOIs
StatePublished - Jun 2003

Keywords

  • atherosclerosis
  • cholesterol
  • lipids
  • prevention

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

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