Anti-angiogenic properties of vitreous

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Vitreous is vascularized in the fetus but is avascular through normal adult life. This gel changing from a pro-angiogenic to anti-angiogenic milieu accompanies the loss in vasculature. The avascularity of adult vitreous may be due to the myriad of anti-angiogenic proteins normally present that include transforming growth factor-β, pigment epithelial-derived factor, thrombospondin, and endostatin. In disease states such as diabetic and sickle cell retinopathies, preretinal neovascularization grows from retina into vitreous. These angiogenic events occur when there is a shift in balance between angiogenic factors such as vascular endothelial growth factor and anti-angiogenic factors and the vitreous returns to a pro-angiogenic environment.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Eye, Four-Volume Set
PublisherElsevier
Pages112-119
Number of pages8
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
DOIs
StatePublished - Jan 1 2010

Keywords

  • Angiogenic factor
  • Anti-angiogenic factor
  • Hyalocytes
  • Hyaloid vasculature
  • Neovascularization
  • PEDF
  • TGFβ
  • TSP-1
  • VEGF
  • Vitreous

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lutty, G. A. (2010). Anti-angiogenic properties of vitreous. In Encyclopedia of the Eye, Four-Volume Set (pp. 112-119). Elsevier. https://doi.org/10.1016/B978-0-12-374203-2.00261-X