Anti-angiogenic properties of vitreous

Zubair Ahmed, Gerard A. Lutty

Research output: Chapter in Book/Report/Conference proceedingChapter


Vitreous is vascularized in the fetus but is avascular through normal adult life. This gel changing from a pro-angiogenic to anti-angiogenic milieu accompanies the loss in vasculature. The avascularity of adult vitreous may be due to the myriad of anti-angiogenic proteins normally present that include transforming growth factor-β, pigment epithelial-derived factor, thrombospondin, and endostatin. In disease states such as diabetic and sickle cell retinopathies, preretinal neovascularization grows from retina into vitreous. These angiogenic events occur when there is a shift in balance between angiogenic factors such as vascular endothelial growth factor and anti-angiogenic factors and the vitreous returns to a pro-angiogenic environment.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages8
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016


  • Angiogenic factor
  • Anti-angiogenic factor
  • Hyalocytes
  • Hyaloid vasculature
  • Neovascularization
  • PEDF
  • TGFβ
  • TSP-1
  • VEGF
  • Vitreous

ASJC Scopus subject areas

  • Medicine(all)


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