Anti-angiogenic peptides for cancer therapeutics

Elena V. Rosca, Jacob E. Koskimaki, Corban G. Rivera, Niranjan B. Pandey, Amir P. Tamiz, Aleksander S. Popel

Research output: Contribution to journalArticle

Abstract

Peptides have emerged as important therapeutics that are being rigorously tested in angiogenesis-dependent diseases due to their low toxicity and high specificity. Since the discovery of endogenous proteins and protein fragments that inhibit microvessel formation (thrombospondin, endostatin) several peptides have shown promise in pre-clinical andclinical studies for cancer. Peptides have been derived from thrombospondin, collagens, chemokines, coagulation cascadeproteins, growth factors, and other classes of proteins and target different receptors. Here we survey recent developments for anti-angiogenic peptides with length not exceeding 50 amino acid residues that have shown activity in pre-clinicalmodels of cancer or have been tested in clinical trials; some of the peptides have been modified and optimized, e.g.,through L-to-D and non-natural amino acid substitutions. We highlight technological advances in peptide discovery andoptimization including computational and bioinformatics tools and novel experimental techniques.

Original languageEnglish (US)
Pages (from-to)1101-1116
Number of pages16
JournalCurrent Pharmaceutical Biotechnology
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2011

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Keywords

  • Angiogenesis
  • Animal model
  • Computational biology
  • In vitro model
  • Inhibitor
  • Peptidomimetics
  • Tumor
  • Tumor vasculature

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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